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陈园, 杜利新, 李涛, 王文宇, 邹龙.芍药苷对心血管疾病的药理作用及其新型药物制剂的研究进展[J].湖南中医药大学学报英文版,2025,45(7):1394-1400.[Click to copy
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| 芍药苷对心血管疾病的药理作用及其新型药物制剂的研究进展 |
| 陈园,杜利新,李涛,王文宇,邹龙 |
| (湖南中医药大学药学院, 湖南 长沙 410208) |
| 摘要: |
| 芍药苷是芍药科植物中主要且具有代表性的活性成分，在心血管疾病的防治中展现出广泛的药理作用，包括抗动脉粥样硬化、抗心肌梗死、抗血栓及改善心肌缺血再灌注等。然而，其临床应用受到稳定性差、溶解度低、代谢快和口服吸收效率低等因素限制。针对这一难题，近年来多种新型递药系统相继开发，包括微乳、脂质体、磷脂复合物、纳米粒和凝胶剂等，部分制剂在动物实验中显示出良好的组织靶向性和治疗效果。本文总结芍药苷对心血管疾病的保护作用，梳理其剂型优化的最新进展，旨在为其后续药物开发与临床转化提供参考依据。 |
| 关键词: 芍药苷 心血管疾病 新剂型 生物利用度 制剂研究 新型递药系统 |
| DOI：10.3969/j.issn.1674-070X.2025.07.030 |
| Received:January 22, 2025 |
| 基金项目:湖南省研究生科研创新课题项目（CX20230830）。 |
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| Recent advances in the pharmacological effects of Paeoniflorin on cardiovascular diseases and its novel pharmaceutical formulations |
| CHEN Yuan, DU Lixin, LI Tao, WANG Wenyu, ZOU Long |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| As a major and representative bioactive compound derived from plants of the Ranunculaceae family, Paeoniflorin has demonstrated a wide range of pharmacological effects in the prevention and treatment of cardiovascular diseases (CVDs), including anti-atherosclerotic, anti-myocardial infarction, anti-thrombotic activities, as well as the amelioration of myocardial ischemia-reperfusion injury. However, its clinical application is hindered by poor stability, low solubility, rapid metabolism, and limited oral bioavailability. To address these challenges, a variety of novel drug delivery systems have been developed in recent years, such as microemulsions, liposomes, phospholipid complexes, nanoparticles, and hydrogels. Some of these formulations have shown promising tissue-targeting properties and therapeutic efficacy in animal studies. This paper summarizes the cardioprotective effects of Paeoniflorin on CVDs and outlines recent advances in formulation optimization, aiming to provide a reference for its further pharmaceutical development and clinical translation. |
| Key words: Paeoniflorin cardiovascular disease novel formulation bioavailability formulation research new drug delivery system |
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