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李伟军, 甘子杰, 林雪峰, 廉坤, 孟骊冲, 胡志希.中医药调控Wnt/β-catenin通路治疗慢性心力衰竭的作用机制[J].湖南中医药大学学报英文版,2025,45(7):1378-1385.[Click to copy
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| 中医药调控Wnt/β-catenin通路治疗慢性心力衰竭的作用机制 |
| 李伟军,甘子杰,林雪峰,廉坤,孟骊冲,胡志希 |
| (湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 慢性心力衰竭（CHF）作为终末期心血管疾病，具有复杂的病理机制，其发病过程不仅涉及心肌细胞结构和功能的改变，还包括炎症反应、氧化应激、神经内分泌系统失调以及血管功能异常等多个环节。其中，中医药在调控Wnt/β-连环蛋白（β-catenin）信号通路方面展现出独特优势，为CHF的治疗提供了多层次、多途径的干预手段。本研究基于Wnt/β-catenin信号通路，通过解析其异常活化，促进心肌纤维化、抑制心肌再生及加剧氧化应激的级联机制，阐明该通路驱动CHF发展的病理学本质。系统阐释中医药干预Wnt/β-catenin信号通路的关键靶标，为基于该通路干预CHF的治疗策略提供实验依据，同时为今后进一步深入研究CHF提供理论依据和实践基础。 |
| 关键词: 慢性心力衰竭 Wnt/β-catenin信号通路 心肌纤维化 炎症反应 氧化应激 |
| DOI：10.3969/j.issn.1674-070X.2025.07.028 |
| Received:February 17, 2025 |
| 基金项目:国家自然科学基金项目（82274412）；国家中医药管理局高水平中医药重点学科建设项目（zyyzdxk-2023147）。 |
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| Mechanism of action of Chinese medicine in regulating the Wnt/β-catenin pathway for the treatment of chronic heart failure |
| LI Weijun, GAN Zijie, LIN Xuefeng, LIAN Kun, MENG Lichong, HU Zhixi |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Chronic heart failure (CHF), as an end-stage cardiovascular disease, has a complex pathological mechanism. Its pathogenesis involves not only changes in the structure and function of cardiomyocytes, but also multiple processes such as inflammatory response, oxidative stress, neuroendocrine system dysregulation, and vascular dysfunction. Among them, Chinese medicine has demonstrated unique advantages in regulating this signaling pathway, providing multi-level and multi-pathway intervention approaches for the treatment of CHF. Based on the Wnt/β-catenin signaling pathway, the present study elucidated the pathological nature of CHF progression driven by its abnormal activation, which promotes myocardial fibrosis, inhibits myocardial regeneration, and exacerbates oxidative stress through a cascade mechanism. The study systematically elucidates the key targets of TCM intervention in the Wnt/β-catenin signaling pathway, providing experimental evidence for the development of therapeutic strategies targeting this pathway in CHF. Meanwhile, it offers a theoretical foundation and practical basis for further in-depth research on CHF in the future. |
| Key words: chronic heart failure Wnt/β-catenin signaling pathway myocardial fibrosis inflammatory response oxidative stress |
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