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郭紫薇, 姚子昂, 汪九重, 吴东杰, 吕文良.基于“脾肾相关”理论探讨肌肉减少症与代谢相关脂肪性肝病的相关性[J].湖南中医药大学学报英文版,2025,45(7):1338-1344.[Click to copy
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| 基于“脾肾相关”理论探讨肌肉减少症与代谢相关脂肪性肝病的相关性 |
| 郭紫薇,姚子昂,汪九重,吴东杰,吕文良 |
| (中国中医科学院广安门医院感染疾病科, 北京 100053;北京大学人民医院中医科, 北京 100029) |
| 摘要: |
| 代谢相关脂肪性肝病（MAFLD）已成为全球范围内最常见的慢性肝病之一，常与肌肉减少症并发。二者在发病机制上具有诸多共同点，其中胰岛素抵抗被认为是其核心驱动因素，此外，慢性炎症反应、线粒体功能障碍及肠道菌群失衡等因素亦在疾病进展中发挥重要作用。肌肉减少症与MAFLD之间存在复杂而双向的生理病理联系。中医学认为，“肾主骨生髓”“脾主肌肉”，肾为先天之本，脾为后天之本。本文基于“脾肾相关”理论，探讨肌肉减少症与MAFLD的双向联系，分析其交叉共病的中西医机制，并归纳其辨证论治思路，旨在为相关防治策略提供新思路与新方法。 |
| 关键词: 肌肉减少症 代谢相关脂肪性肝病 脾肾相关 脏腑理论 代谢性疾病 理论探讨 |
| DOI：10.3969/j.issn.1674-070X.2025.07.021 |
| Received:February 07, 2025 |
| 基金项目:中央高水平中医医院临床研究和成果转化能力提升项目——传承名老中医药专家学术经验专项（HLCMHPP2023013）。 |
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| Correlation between sarcopenia and metabolic associated fatty liver disease based on the theory of "spleen-kidney being related" |
| GUO Ziwei, YAO Zi'ang, WANG Jiuchong, WU Dongjie, LYU Wenliang |
| (Department of Infectious Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;Department of Chinese Medicine, Peking University People's Hospital, Beijing 100029, China) |
| Abstract: |
| Metabolic associated fatty liver disease (MAFLD) has become one of the most common chronic liver diseases worldwide and often coexists with sarcopenia. The two conditions share many commonalities in their pathogenesis, among which insulin resistance is regarded as the core driving factor. Additionally, chronic inflammatory responses, mitochondrial dysfunction, and gut microbiota dysbiosis also critically implicated in the pathogenesis and progression of these conditions. Emerging evidence from the literature suggests a complex bidirectional pathophysiological interplay between sarcopenia and MAFLD. In Chinese medicine, it is asserted that "the kidney governs bone and marrow", "the spleen governs the muscles", and the kidney constitutes the innate foundation and the spleen serves as the acquired foundation of vitality. Based on the "spleen-kidney being related" theory, this study investigates the bidirectional relationship between sarcopenia and MAFLD, analyzes the mechanisms underlying their comorbidity from both Chinese and Western medical perspectives, and summarizes the principles of pattern differentiation and treatment aiming to advance precision medicine approaches for related prevention and treatment strategies. |
| Key words: sarcopenia metabolic associated fatty liver disease spleen-kidney being related zang-fu organ theory metabolic diseases theoretical discussion |
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