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陈喜丽, 张明月, 阳艳, 廖雨虹, 曹徵良, 娄必丹, 汤伟, 夏云.针刺结合康复训练对孤独症谱系障碍患儿的临床疗效及对血清Glu、GABA的影响[J].湖南中医药大学学报英文版,2025,45(7):1285-1289.[Click to copy
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| 针刺结合康复训练对孤独症谱系障碍患儿的临床疗效及对血清Glu、GABA的影响 |
| 陈喜丽,张明月,阳艳,廖雨虹,曹徵良,娄必丹,汤伟,夏云 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察针刺疗法结合康复训练对孤独症谱系障碍（ASD）患儿的临床疗效及对血清谷氨酸（Glu）、γ-氨基丁酸（GABA）的影响。方法 选取2022年4月至2024年6月湖南中医药大学第一附属医院儿童康复专科门诊部、住院部收治的60名ASD患儿，按照随机数字表法分为观察组和对照组，每组30例。对照组予以常规康复训练，观察组在对照组基础上予以针刺疗法，选取头部腧穴（百会、印堂、神庭、本神、四神聪）及心经、心包经腧穴（神门、通里、少海、内关、大陵），每天1次，每周治疗6次，4周为1个疗程，连续治疗3个疗程。比较两组患儿治疗前后的儿童孤独症评定量表（CARS）评分、盖塞尔发育诊断量表的发育商（DQ）评分、社会生活能力量表（SM）评分及血清Glu、GABA变化，评价临床疗效。结果 与治疗前比较，治疗后两组患儿CARS评分较治疗前下降（P＜0.01），且观察组低于对照组（P＜0.01）；DQ评分、SM评分较治疗前升高（P＜0.01），且观察组高于对照组（P＜0.01）。治疗后，两组患儿血清Glu、GABA含量均较治疗前升高（P＜0.01），且观察组高于对照组（P＜0.05，P＜0.01）。结论 在常规康复训练的基础上联合针刺疗法可有效改善ASD患儿的临床症状、提高智能水平及社会适应能力，升高患儿的血清Glu、GABA含量。 |
| 关键词: 孤独症谱系障碍 针刺 康复训练 谷氨酸 γ-氨基丁酸 智能 社会适应能力 |
| DOI：10.3969/j.issn.1674-070X.2025.07.012 |
| Received:January 22, 2025 |
| 基金项目:湖南省中医药管理局科研项目（D2022013）；湖南省卫生健康委员会科研项目（D202314048108）。 |
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| Clinical efficacy of acupuncture combined with rehabilitation training in children with autism spectrum disorder and its effects on serum Glu and GABA |
| CHEN Xili, ZHANG Mingyue, YANG Yan, LIAO Yuhong, CAO Zhengliang, LOU Bidan, TANG Wei, XIA Yun |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the clinical efficacy of acupuncture therapy combined with rehabilitation training in children with autism spectrum disorder (ASD) and its effects on serum glutamate (Glu) and γ-aminobutyric acid (GABA). Methods A total of 60 children with ASD admitted to the Pediatric Rehabilitation Department of the First Hospital of Hunan University of Chinese Medicine from April 2022 to June 2024 were selected and randomly divided into an observation group and a control group according to the random number table method, with 30 cases in each group. The control group received conventional rehabilitation training, while the observation group received acupuncture therapy in addition to the conventional rehabilitation training. The acupuncture points selected included head acupoints[Baihui (GV20), Yintang (EX-HN3), Shenting (GV24), Benshen (GB13), and Sishencong (EX-HN1)], as well as points on the heart meridian and pericardium meridian[Shenmen (HT7), Tongli (HT5), Shaohai (HT3), Neiguan (PC6), and Daling (PC7)]. The treatment was administered once daily, six times per week, with 4 weeks as one course of treatment, and a total of three consecutive courses. The Childhood Autism Rating Scale (CARS) scores, Developmental Quotient (DQ) score of the Gesell Developmental Diagnosis Scale, Social Maturity Scale (SM) score, and changes in serum Glu and GABA levels were compared between the two groups before and after treatment to evaluate the clinical efficacy. Results Compared with those before treatment, the CARS scores of children in both groups decreased after treatment (P<0.01), and the observation group had lower scores than the control group (P<0.01). The DQ and SM scores increased after treatment (P<0.01), and the observation group had higher scores than the control group (P<0.01). After treatment, the serum Glu and GABA levels in both groups increased compared with before treatment (P<0.01), and the observation group had higher levels than the control group (P<0.05, P<0.01). Conclusion Combining acupuncture therapy with conventional rehabilitation training can effectively alleviate the clinical symptoms of children with ASD, enhance their intellectual level and social adaptability, and increase the serum levels of Glu and GABA. |
| Key words: autism spectrum disorder acupuncture rehabilitation training Glutamate γ-aminobutyric acid intellectual level social adaptability |
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