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郭梦月, 郭昌庭, 陈向云, 路雨昕, 李尧锋.中医药对心肌缺血再灌注诱发线粒体损伤保护机制的研究进展[J].湖南中医药大学学报英文版,2025,45(10):1998-2006.[Click to copy
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| 中医药对心肌缺血再灌注诱发线粒体损伤保护机制的研究进展 |
| 郭梦月,郭昌庭,陈向云,路雨昕,李尧锋 |
| (贵州中医药大学基础中医学院, 贵州 贵阳 550025;大理白族自治州妇幼保健院, 云南 大理 671000;大理白族自治州人民医院, 云南 大理 671000;贵州中医药大学基础医学院, 贵州 贵阳 550025) |
| 摘要: |
| 心肌缺血再灌注损伤（MIRI）是临床心血管疾病治疗中的重大挑战，其病理机制复杂，以线粒体功能障碍为关键环节之一。鉴于线粒体在MIRI发生发展的枢纽地位，亟须寻求能够多层面维持其稳态的综合干预策略。中医药在调控线粒体氧化应激、钙超载、通透性转换孔（mPTP）开放、炎症反应、线粒体融合与分裂以及细胞凋亡等方面展现出独特优势。本文系统综述中药在维持线粒体稳态中的多靶点调控机制，进一步阐明中药可通过改善线粒体膜电位、调节能量代谢、恢复线粒体动态平衡并规范细胞凋亡程序，从而发挥综合抗凋亡、抗氧化等作用，研究还探讨了核因子-κB（NF-κB）/核因子红系2相关因子2（Nrf2）/血红素加氧酶-1（HO-1）等信号通路在中药干预中的作用，提示中医药通过多成分、多靶点、多路径干预线粒体损伤，在MIRI防治中具有独特优势。 |
| 关键词: 心肌缺血再灌注损伤 线粒体损伤 中医药 线粒体氧化应激 线粒体钙超载 线粒体通透性转换孔 |
| DOI：10.3969/j.issn.1674-070X.2025.10.029 |
| Received:May 14, 2025 |
| 基金项目:国家自然科学基金地区项目（82360965）。 |
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| Research progress on the protective mechanisms of Chinese medicine against mitochondrial damage induced by myocardial ischemia-reperfusion |
| GUO Mengyue, GUO Changting, CHEN Xiangyun, LU Yuxin, LI Yaofeng |
| (School of Basic Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550025, China;Dali Bai Autonomous Prefecture Maternal and Child Health Hospital, Dali, Yunnan 671000, China;Dali Bai Autonomous Prefecture People's Hospital, Dali, Yunnan 671000, China;School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550025, China) |
| Abstract: |
| Myocardial ischemia-reperfusion injury (MIRI) poses a significant challenge in the clinical therapy of cardiovascular diseases, with complex pathological mechanisms in which mitochondrial dysfunction constitutes a pivotal point. Given the central role of mitochondria in the onset and progression of MIRI, there is an urgent need for integrated intervention strategies that can maintain mitochondrial homeostasis at multiple levels. Chinese medicine shows distinctive advantages in modulating mitochondrial oxidative stress, calcium overload, opening of the mitochondrial permeability transition pore (mPTP), inflammatory responses, mitochondrial fusion and fission, and apoptosis. This review systematically summarizes the multi-target regulatory mechanisms by which Chinese medicines maintain mitochondrial homeostasis, further elucidating that they can improve mitochondrial membrane potential, regulate energy metabolism, restore mitochondrial dynamic balance, and regulate apoptotic process, thereby exerting combined anti-apoptotic and antioxidant effects. Additionally, the roles of signaling pathways, such as nuclear factor kappa B (NF-κB), nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1), in Chinese medicine interventions are discussed. These findings highlight the unique advantages of Chinese medicine in the prevention and treatment of MIRI by mitigating mitochondrial damage through multi-component, multi-target, and multi-pathway mechanisms. |
| Key words: myocardial ischemia-reperfusion injury mitochondrial damage Chinese medicine mitochondrial oxidative stress mitochondrial calcium overload mitochondrial permeability transition pore |
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