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房立广, 高丹丹, 王彤, 赵海军, 王世军, 张亚楠.基于热气生浊理论分期辨治肺癌[J].湖南中医药大学学报英文版,2025,45(10):1943-1947.[Click to copy
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| 基于热气生浊理论分期辨治肺癌 |
| 房立广,高丹丹,王彤,赵海军,王世军,张亚楠 |
| (山东中医药大学中医学院, 山东 济南 250355;山东中医药大学第一临床医学院, 山东 济南 250014;山东中医药大学护理学院, 山东 济南 250355;山东省经典名方协同创新中心, 山东 济南 250355;山东中医药大学医学院, 山东 济南 250355) |
| 摘要: |
| 热气生浊理论是对肺癌病机的完整总结，基于此理论将肺癌发病全程总结为寒气生浊、邪聚成形，寒极生热、化生毒浊和热气生浊、毒浊流注3个阶段。其中，寒气生浊是肺癌的初始病机，寒极生热是肺癌恶性转化、化生毒浊的关键步骤，而热气生浊则是肺癌进展和转移的核心病理过程。基于此理论，本文认为泽漆汤是治疗肺癌的核心用方。在临床实践中，根据疾病所处的不同病程阶段结合肺癌的病理分型辨证论治，成形期温阳去浊、化毒期解毒泄浊、流注期扶正化浊，以期提高肺癌的中医治疗疗效。 |
| 关键词: 热气生浊 肺癌 分期论治 泽漆汤 《黄帝内经》 |
| DOI：10.3969/j.issn.1674-070X.2025.10.019 |
| Received:July 05, 2025 |
| 基金项目:国家自然科学基金面上项目（82374178，82174117）；山东省自然科学基金面上项目（ZR2022MH180）；山东中医药大学博士研究生提质创新课题（YJSTZCX2024018）。 |
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| Stage-based pattern differentiation and treatment of lung cancer based on the theory of "heat qi generates turbidity" |
| FANG Liguang, GAO Dandan, WANG Tong, ZHAO Haijun, WANG Shijun, ZHANG Ya'nan |
| (School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China;The First Clinical Medical School, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China;School of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China;Shandong Co-Innovation Center of Classic TCM Formulas, Jinan, Shandong 250355, China;School of Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China) |
| Abstract: |
| The theory of "heat qi generates turbidity" constitutes a comprehensive summary of the pathogenesis of lung cancer. According to this theory, the entire course of lung cancer development is categorized into three stages: generation of turbidity by cold qi and aggregation of pathogenic factors into a mass; extreme cold giving rise to heat, resulting in transformation into toxic turbidity; and generation of turbidity by heat qi, characterized by the dissemination and flow of toxic turbidity. Among these, generation of turbidity by cold qi represents the initial pathological mechanism of lung cancer; extreme cold giving rise to heat is the critical step for malignant transformation and formation of toxic turbidity in lung cancer; generation of turbidity by heat qi is the core pathological process underlying the progression and metastasis of lung cancer. Based on this theory, this article identifies Zeqi Decoction as the core formula for the treatment of lung cancer. In clinical practice, pattern differentiation and treatment are conducted based on the disease staging and the pathological classification of lung cancer: during the turbidity-generating stage, warming yang and eliminating turbidity are employed; during the toxic turbidity-transforming stage, removing toxins and reducing turbidity are applied; during the toxic turbidity-disseminating stage, reinforcing healthy qi and resolving turbidity are utilized. This approach aims to improve the efficacy of Chinese medicine in the treatment of lung cancer. |
| Key words: heat qi generates turbidity lung cancer stage-based treatment Zeqi Decoction Huang Di Nei Jing (Huangdi's Classic of Medicine) |
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