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何欣, 付雪, 吕凤琼, 唐春梅, 邓波, 吴仕平.黄芪颗粒治疗老年肌少症的临床疗效及对IL-33/ST2信号通路相关细胞因子的影响[J].湖南中医药大学学报英文版,2026,46(2):387-393.[Click to copy
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| 黄芪颗粒治疗老年肌少症的临床疗效及对IL-33/ST2信号通路相关细胞因子的影响 |
| 何欣,付雪,吕凤琼,唐春梅,邓波,吴仕平 |
| (遂宁市中心医院全科医学科, 四川 遂宁 629000) |
| 摘要: |
| 目的 观察黄芪颗粒治疗老年肌少症患者的临床疗效，并探讨其对IL-33/ST2信号通路相关细胞因子的调控作用。方法 选取2024年7月至2025年7月遂宁市中心医院收治的100例老年肌少症患者为研究对象，采用随机数字表法将其分为对照组和观察组，每组50例。对照组行基础治疗（包括营养支持和抗阻运动指导，连续治疗8周）；观察组在对照组基础上另加黄芪颗粒治疗（每次15 g，每日早晚各1次，连续治疗8周）。采用生物电阻抗法评估患者治疗前后四肢骨骼肌质量指数（ASMI）；采用握力计检测患者治疗前后优势手握力；观察患者治疗前后6 m步行速度；简易体能状况量表（SPPB）评分评估患者治疗前后肌肉活动能力；ELISA检测患者治疗前后血清肌酐（Cr）、胱抑素C（Cys C）、肌肉生长抑制素（MSTN）、肌肉减少指数（SI）、白细胞介素（IL）-33、肿瘤抑制因子2（ST2）、IL-6、IL-10含量；评估治疗后患者的临床疗效；评估治疗方案的安全性。结果 与治疗前比较，治疗后两组患者ASMI、握力、6 m步行速度、SPPB评分、血清IL-33、ST2和IL-10的含量均升高（P＜0.05），且观察组高于对照组（P＜0.05）；与治疗前比较，治疗后两组患者血清MSTN和IL-6含量均降低（P＜0.05），且观察组低于对照组（P＜0.05）；治疗后，观察组总有效率高于对照组（P＜0.05）；治疗过程中两组患者均未发生不良反应。结论 黄芪颗粒治疗老年肌少症患者的临床疗效显著，其机制可能与激活IL-33/ST2信号通路，降低促炎性细胞因子IL-6的含量，升高抗炎细胞因子IL-10的含量有关。 |
| 关键词: 黄芪颗粒 老年肌少症 炎症 白细胞介素-33 肿瘤抑制因子2 |
| DOI：10.3969/j.issn.1674-070X.2026.02.024 |
| Received:November 11, 2025 |
| 基金项目:四川省2024年度中医药科研专项课题(2024MS407)。 |
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| Clinical efficacy of Huangqi Granule in treating sarcopenia in the elderly and its effects on IL-33/ST2 signaling pathway-related cytokines |
| HE Xin, FU Xue, LYU Fengqiong, TANG Chunmei, DENG Bo, WU Shiping |
| (Department of General Practice, Suining Central Hospital, Suining, Sichuan 629000, China) |
| Abstract: |
| Objective To observe the clinical efficacy of Huangqi Granule in treating elderly patients with sarcopenia and explore its regulatory effects on cytokines related to the IL-33/ST2 signaling pathway. Methods A total of 100 elderly patients with sarcopenia admitted to Suining Central Hospital from July 2024 to July 2025 were selected as the study subjects. They were randomly divided into a control group and an observation group using a random number table method, with 50 cases in each group. The control group received basic treatment (including nutritional support and resistance exercise guidance, for 8 consecutive weeks), while the observation group received additional Huangqi Granule treatment (15 g per dose, twice daily, morning and evening, for 8 consecutive weeks) based on the control group's treatment. The appendicular skeletal muscle mass index (ASMI) was assessed using bioelectrical impedance analysis before and after treatment. Grip strength of the dominant hand was measured using a dynamometer before and after treatment. The 6-meter walking speed was observed before and after treatment. Muscle function was evaluated using the Short Physical Performance Battery (SPPB) score before and after treatment. ELISA was used to measure the serum levels of creatinine (Cr), cystatin C (CysC), myostatin (MSTN), sarcopenia index (SI), interleukin (IL)-33, suppressor of tumorigenicity 2 (ST2), IL-6, and IL-10 before and after treatment. The clinical efficacy and safety of the treatment regimens were evaluated after treatment. Results Compared with before treatment, the ASMI, grip strength, 6-meter walking speed, SPPB score, and serum levels of IL-33, ST2, and IL-10 increased in both groups after treatment (P<0.05), with higher values observed in the observation group than in the control group (P<0.05). Compared with before treatment, the serum levels of MSTN and IL-6 decreased in both groups after treatment (P<0.05), with lower values observed in the observation group than in the control group (P<0.05). After treatment, the total effective rate was higher in the observation group than in the control group (P<0.05). No adverse reactions occurred in either group during the treatment process. Conclusion Huangqi Granule demonstrate significant clinical efficacy in the treatment of elderly patients with sarcopenia. The mechanism may be related to the activation of the IL-33/ST2 signaling pathway, which reduces the level of the pro-inflammatory cytokine IL-6 and increases the level of the anti-inflammatory cytokine IL-10. |
| Key words: Huangqi Granule sarcopenia in the elderly inflammation interleukin-33 suppressor of tumorigenicity 2 |
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