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陈凯铭, 郝晓凤, 谢立科, 张孟姣, 鞠品, 孙梅, 祁怡馨.基于“虚劳干血”理论论治难治性视网膜静脉阻塞的探讨[J].湖南中医药大学学报英文版,2026,46(2):360-364.[Click to copy
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| 基于“虚劳干血”理论论治难治性视网膜静脉阻塞的探讨 |
| 陈凯铭,郝晓凤,谢立科,张孟姣,鞠品,孙梅,祁怡馨 |
| (中国中医科学院眼科医院, 北京 100040) |
| 摘要: |
| 难治性视网膜静脉阻塞（RVO）常表现为反复的黄斑水肿、视网膜缺血及新生血管形成等，临床治疗手段有限，疗效不佳。中医学从血瘀论治难治性RVO，临床疗效常不理想。“虚劳干血”理论源于《金匮要略》，旨在阐述“虚损为本，干血内结”的核心病机。本文基于“虚劳干血”理论，将难治性RVO病机阐释为“虚-瘀-干血”的演变过程，并根据干血形成的不同阶段，提出分型论治：对于干血初成期，以化瘀通络、软坚散结为法，主以血府逐瘀汤合鳖甲煎丸；对于干血内结期，则恪守缓中补虚、祛瘀生新之旨，以大黄䗪虫丸为代表方。本研究旨在为难治性RVO防治提供新的中医辨治思路与理论依据。 |
| 关键词: 难治性视网膜静脉阻塞 干血 虚劳 分期论治 血府逐瘀汤 鳖甲煎丸 大黄䗪虫丸 |
| DOI：10.3969/j.issn.1674-070X.2026.02.020 |
| Received:October 30, 2025 |
| 基金项目:国家自然科学基金面上项目(82474582);中国中医科学院眼科医院高水平中医医院课题(GSP5-83);中国中医科学院眼科医院高水平中医医院揭榜挂帅项目(GSP4-02)。 |
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| Treating refractory retinal vein occlusion based on the theory of “consumption with dry blood stasis” |
| CHEN Kaiming, HAO Xiaofeng, XIE Like, ZHANG Mengjiao, JU Pin, SUN Mei, QI Yixin |
| (Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China) |
| Abstract: |
| Refractory retinal vein occlusion (RVO) frequently manifests as recurrent macular edema, retinal ischemia, and neovascularization. Clinical treatment options are limited, and the therapeutic efficacy is often unsatisfactory. Chinese Medicine often treats refractory RVO from the perspective of blood stasis, and the clinical outcomes are frequently suboptimal. The theory of "consumption with dry blood stasis", originating from the Jin Gui Yao Lue (Essentials from the Golden Cabinet), elucidates the core pathogenesis of "deficiency-consumption as the root, with internal accumulation of blood stasis". Based on this theory, this article interprets the pathogenesis of refractory RVO as an evolutionary process of "deficiency-stagnant blood-dry blood stasis." Furthermore, according to different stages of dry blood stasis, a staged differentiation and treatment approach is proposed:for the initial stage of dry blood stasis formation, the treatment principle focuses on resolving stasis and unblocking collaterals, as well as softening hardness and dispersing nodules. The primary formula is Xuefu Zhuyu Decoction combined with Biejiajian Pill. For the stage of internal accumulation of dry blood stasis, the treatment adheres to the principle of "relieving the middle jiao and tonifying deficiency, removing stasis to promote regeneration," represented by Dahuang Zhechong Pill. This study aims to provide a new TCM diagnostic and therapeutic framework, along with a theoretical basis, for the prevention and treatment of refractory RVO. |
| Key words: refractory retinal vein occlusion dry blood stasis consumption stage-based treatment Xuefu Zhuyu Decoction Biejiajian Pill Dahuang Zhechong Pill |
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