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程惠专, 周丽琼, 朱芙蓉.中药雾化熏眼联合艾灸在非增殖性糖尿病视网膜病变阴虚夹瘀证患者中的应用效果[J].湖南中医药大学学报英文版,2026,46(2):305-310.[Click to copy
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| 中药雾化熏眼联合艾灸在非增殖性糖尿病视网膜病变阴虚夹瘀证患者中的应用效果 |
| 程惠专,周丽琼,朱芙蓉 |
| (湖南中医药大学第一附属医院眼科, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察中药雾化熏眼联合艾灸在非增殖性糖尿病视网膜病变（NPDR）阴虚夹瘀证患者中的应用效果。方法 选取2021年12月至2024年12月就诊于湖南中医药大学第一附属医院眼科的NPDR阴虚夹瘀证患者82例（164眼）。随机分为对照组与观察组，各41例（82眼）。两组患者均予以西医常规治疗及中药雾化熏眼治疗，观察组在此基础上联合穴位艾灸治疗。持续治疗3个月后，比较治疗前后两组患者最佳矫正视力（BCVA）水平，眼底微血管瘤数量、出血点数量、微血管病变面积，中医证候积分，血清血管内皮生长因子（VEGF）、胎盘生长因子（PLGF）水平以及治疗后临床总有效率、不良反应。结果 与治疗前比较，治疗后两组患者BCVA水平均提高（P＜0.05），且观察组高于对照组（P＜0.05）；治疗后两组患者眼底微血管瘤数量、出血点数量、微血管病变面积均少于治疗前（P＜0.05），且观察组少于对照组（P＜0.05）；治疗后两组患者中医证候积分及VEGF、PLGF水平均低于治疗前（P＜0.05），且观察组较对照组更低（P＜0.05）。治疗后观察组总有效率（92.7%）高于对照组（68.3%）（P＜0.05）。两组均未发生不良反应。结论 运用中药雾化熏眼联合艾灸治疗NPDR阴虚夹瘀证患者可改善患者的视力、眼底病变及中医证候，具有良好的安全性。 |
| 关键词: 非增殖性糖尿病视网膜病变 中药雾化 艾灸 疗效 |
| DOI：10.3969/j.issn.1674-070X.2026.02.011 |
| Received:September 24, 2025 |
| 基金项目:国家中医优势专科-护理学(国中医药医政函[2024]90号)。 |
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| Therapeutic effects of nebulized Chinese medicine eye fumigation combined with moxibustion in non-proliferative diabetic retinopathy patients with yin deficiency complicated by blood stasis pattern |
| CHENG Huizhuan, ZHOU Liqiong, ZHU Furong |
| (Department of Ophthalmology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the therapeutic effects of nebulized Chinese medicine eye fumigation combined with moxibustion in non-proliferative diabetic retinopathy (NPDR) patients with yin deficiency complicated by blood stasis pattern. Methods A total of 82 NPDR patients (164 eyes) with yin deficiency complicated by blood stasis pattern treated at the Department of Ophthalmology of the First Hospital of Hunan University of Chinese Medicine from December 2021 to December 2024 were enrolled. They were randomly divided into a control group and an observation group, with 41 cases (82 eyes) in each group. Both groups received conventional Western medicine and eye fumigation with nebulized Chinese medicines, while the observation group underwent additional acupoint moxibustion. After three months of continuous treatment, the best correct visual acuity (BCVA), numbers of fundus microaneurysms and hemorrhagic spots, area of microvascular lesions, Chinese medicine pattern scores, and serum levels of vascular endothelial growth factor (VEGF) and placental growth factor (PLGF) were compared between groups before and after treatment. Post-treatment total clinical effective rate and adverse reactions were also evaluated. Results Compared with pre-treatment levels, both groups showed improvement in BCVA after treatment (P<0.05), with the observation group demonstrating superior outcomes to the control group (P<0.05). Following treatment, the numbers of fundus microaneurysms and hemorrhagic spots, as well as the area of microvascular lesions were all reduced compared to pre-treatment values in both groups (P<0.05), and the observation group had significantly lower values than the control group (P<0.05). The Chinese medicine pattern scores and levels of VEGF and PLGF in both groups were lower than those before treatment (P<0.05), with the observation group showing significantly lower levels than the control group (P<0.05). The total effective rate in the observation group (92.7%) was significantly higher than that in the control group (68.3%) (P<0.05). No adverse reactions occurred in either group. Conclusion The application of nebulized Chinese medicine eye fumigation combined with moxibustion in treating NPDR patients with yin deficiency complicated by blood stasis pattern can improve the patients' visual acuity, fundus lesions, and Chinese medicine pattern scores, with favorable safety. |
| Key words: non-proliferative diabetic retinopathy Chinese medicine nebulization moxibustion therapeutic effects |
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