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袁野, 于海睿, 皇甫海全, 刘怡雯, 刘彩惠, 赵钢, 范增光.基于外泌体-细胞衰老交互作用机制探讨中药复方抗动脉粥样硬化的研究进展[J].湖南中医药大学学报英文版,2025,45(11):2225-2231.[Click to copy
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| 基于外泌体-细胞衰老交互作用机制探讨中药复方抗动脉粥样硬化的研究进展 |
| 袁野,于海睿,皇甫海全,刘怡雯,刘彩惠,赵钢,范增光 |
| (鸡西市人民医院医疗集团, 黑龙江 鸡西 158119;黑龙江中医药大学, 黑龙江 哈尔滨 150040;江西中医药大学附属医院, 江西 南昌 330006;深圳市罗湖区中医院, 广东 深圳 518000;江西中医药大学, 江西 南昌 330004) |
| 摘要: |
| 外泌体介导的细胞间信息传递与细胞衰老形成的“炎症-衰老循环”，揭示了动脉粥样硬化（AS）的核心病理机制。本研究系统梳理了外泌体与细胞衰老在AS病程中的交互作用机制：一方面，衰老细胞释放的外泌体可携带炎症因子、衰老相关分泌表型（SASP）等物质，诱导邻近细胞发生功能异常与衰老表型转换，加重血管壁炎症状态；另一方面，受损血管内皮细胞、巨噬细胞等分泌的外泌体，又可通过调控微小核糖核酸、蛋白质等信号分子的传递，进一步激活细胞衰老通路，形成恶性循环。这种协同致病模式在脂质代谢紊乱、血管内皮损伤、斑块稳定性失衡等多个病理环节中发挥关键作用。同时，本文系统整合了黄芪桂枝五物汤、血府逐瘀汤等经典中药复方干预AS的相关研究证据，发现此类复方可通过调节外泌体内容物组成、阻断衰老信号通路传递、下调SASP因子表达水平等作用，干预“炎症-衰老循环”的关键环节，为中医药基于该循环机制干预AS提供了具有科学性的理论参考。 |
| 关键词: 动脉粥样硬化 外泌体 炎症-衰老循环 细胞衰老 病理机制 |
| DOI：10.3969/j.issn.1674-070X.2025.11.029 |
| Received:June 23, 2025 |
| 基金项目:国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023113); 江西省自然科学基金项目(20252BAC240452); 江西省卫生健康委员会科技计划项目(202410310); 江西省中医药管理局项目(2024B0153)。 |
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| Research progress on anti-atherosclerotic effects of Chinese medicine compound formulas based on the interaction mechanism between exosomes and cellular senescence |
| YUAN Ye, YU Hairui, HUANGFU Haiquan, LIU Yiwen, LIU Caihui, ZHAO Gang, FAN Zengguang |
| (Jixi People's Hospital Medical Group, Jixi, Heilongjiang 158119, China;Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330006, China;Shenzhen Luohu Hospital of Traditional Chinese Medicine, Shenzhen, Guangdong 518000, China;Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330004, China) |
| Abstract: |
| The "inflammation-senescence cycle" formed by exosome-mediated intercellular communication and cellular senescence reveals the core pathological mechanism of atherosclerosis（AS）. This study systematically combed the interaction mechanisms between exosomes and cellular senescence in the progression of AS. On one hand, exosomes released by senescent cells can carry inflammatory factors, senescence-associated secretory phenotype（SASP）, and other substances, inducing functional abnormalities and senescence phenotype conversion in adjacent cells, thereby exacerbating the inflammatory state of the vascular wall. On the other hand, exosomes secreted by damaged vascular endothelial cells, macrophages, etc., can further activate the cellular senescence pathways by regulating the transmission of signaling molecules such as microRNAs and proteins, forming a vicious cycle. This synergistic pathogenic pattern plays a key role in multiple pathological processes including lipid metabolism disorder, vascular endothelial injury, and plaque stability imbalance. Meanwhile, this paper systematically integrated relevant research evidence in the intervention of AS by classic Chinese medicine compound formulas, such as Huangqi Guizhi Wuwu Decoction and Xuefu Zhuyu Decoction. It is found that these formulas can intervene in key links of the "inflammationsenescence cycle" by regulating t he composition of exosomal contents, blocking the transmission of senescence signaling pathways, and downregulating the expression levels of SASP factors, thus providing a scientific theoretical reference for Chinese medicine to intervene in AS based on this cycle mechanism. |
| Key words: atherosclerosis exosome inflammation-senescence cycle cellular senescence pathological mechanism |
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