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徐淼, 刘泽豪, 刘铜华, 高明, 秦灵灵, 王海焱, 吕翠岩.基于“态靶辨证”探析补肾开玄通络法治疗糖尿病肾病[J].湖南中医药大学学报英文版,2025,45(11):2142-2148.[Click to copy
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| 基于“态靶辨证”探析补肾开玄通络法治疗糖尿病肾病 |
| 徐淼,刘泽豪,刘铜华,高明,秦灵灵,王海焱,吕翠岩 |
| (北京中医药大学, 北京 100029;首都医科大学附属北京中医医院, 北京 100010;日本武库川女子大学, 日本 663-8558) |
| 摘要: |
| 糖尿病肾病（DKD）是糖尿病常见并发症之一，仝小林院士创新性地提出“态靶辨证”理论体系，通过“宏观态-微观靶”相结合的中西医诊疗模式，可有效改善患者水肿、乏力、泡沫尿等临床症状，为DKD临床治疗提供了新的思路与方向。本团队在“肾络玄府”理论的基础上，结合临床实践，提出DKD病程中存在“虚、瘀、浊”三态演变规律，并针对病靶、症靶、标靶，提出运用补肾开玄通络法治疗DKD，强调病证结合、态靶同调，实现分层精准干预。临床实践表明，“态靶辨证”通过中医整体调节与西医靶向治疗的有机融合，在改善DKD临床症状、延缓肾功能进展方面展现出独特优势。 |
| 关键词: 态靶辨证 糖尿病肾病 补肾开玄通络法 靶方 靶药 |
| DOI：10.3969/j.issn.1674-070X.2025.11.016 |
| Received:August 03, 2025 |
| 基金项目:科技部国家重点研发计划政府间国际科技创新合作重点专项项目(2021YFE0106300); 教育部、科研部高等学校学科创新引智计划项目(B20055)。 |
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| Treatment of diabetic kidney disease with kidney-tonifying, mysterious mansion-opening, and collateral-unblocking therapy based on “state-target pattern identification” |
| XU Miao, LIU Zehao, LIU Tonghua, GAO Ming, QIN Lingling, WANG Haiyan, LYU Cuiyan |
| (Beijing University of Chinese Medicine, Beijing 100029, China;Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;Mukogawa Women爷s University, Nishinomiya, Hyogo 663-8558, Japan) |
| Abstract: |
| Diabetic kidney disease（DKD）, one of the prevalent complications of diabetes, has been innovatively addressed through the “state-target pattern identification（STPI）” theoretical framework proposed by Academician TONG Xiaolin. This“macroscopic state and microscopic target” integrated Chinese-Western diagnostic-therapeutic model effectively alleviates clinical symptoms such as edema, fatigue, and frothy urine in DKD patients, thereby providing novel insights for clinical management.Building on the “mysterious mansion of kidney collateral” theory and clinical practice, our team has identified a three-stage evolutionary pattern of “deficiency, stasis, and turbidity” during DKD progression. Correspondingly, we developed a kidney-tonifying,mysterious mansion-opening, and collateral-unblocking therapy aiming to disease-target, symptom-target, and indicator-target. This therapy emphasizes pattern-disease combination and simultaneous state-target regulation, enabling stratified precision intervention.Clinical evidence demonstrates that STPI, through organic integration of TCM holistic regulation and western targeted therapy,exhibits unique advantages in symptom improvement and renal function preservation in DKD. |
| Key words: state-target pattern identification diabetic kidney disease kidney-tonifying,mysterious mansion-opening,and collateral-unblocking therapy target formula target medicine |
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