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胡泽昊, 黄秋璇, 林创坚, 陈国华.基于线粒体质量控制失衡探讨从“玄府-气液”论治膝骨关节炎[J].湖南中医药大学学报英文版,2025,45(5):950-955.[Click to copy
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| This paper
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| 基于线粒体质量控制失衡探讨从“玄府-气液”论治膝骨关节炎 |
| 胡泽昊,黄秋璇,林创坚,陈国华 |
| (广州中医药大学附属汕头中医院 广东 汕头 515031;汕头市中医医院 广东 汕头 515031) |
| 摘要: |
| 膝骨关节炎（KOA）是一种常见的慢性关节病，其发病与线粒体功能障碍及中医“玄府-气液”失衡密切相关。基于线粒体质量控制的作用机制，从“玄府-气液”理论角度论治KOA，提出辛散开玄、祛湿通络畅玄、补益壮玄的中医治法。通过调控玄府开阖，促进气血津液运行，进而改善线粒体功能。本文从线粒体质量控制失衡的角度，深入探究线粒体功能与“玄府-气液”理论的内在联系，为KOA的防治提供更坚实的理论基础。 |
| 关键词: 膝骨关节炎 线粒体质量控制 玄府-气液 慢性骨关节病 理论探讨 |
| DOI：10.3969/j.issn.1674-070X.2025.05.025 |
| Received:December 17, 2024 |
| 基金项目:第七批全国老中医药专家学术经验继承项目（国中医药人教函〔2022〕76 号）；广东省林创坚名中医传承工作室建设项目（粤中医办函〔2017〕170号）。 |
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| Treatment of knee osteoarthritis from the perspective of "mysterious mansion-qi and fluids" theory based on the mitochondrial quality control imbalance |
| HU Zehao, HUANG Qiuxuan, LIN Chuangjian, CHEN Guohua |
| (Shantou Hospital of Traditional Chinese Medicine affiliated to Guangzhou University of Chinese Medicine, Shantou, Guangdong 515031, China;Shantou Hospital of Traditional Chinese Medicine, Shantou, Guangdong 515031, China) |
| Abstract: |
| Knee Osteoarthritis (KOA) is a prevalent chronic joint disorder, the pathogenesis of which is closely associated with mitochondrial dysfunction and the imbalance of "mysterious mansion (the gateways of qi ascending, descending, exiting, and entering in the body)-qi and fluids" in Chinese Medicine. This study integrates the mechanism of mitochondrial quality control with the TCM theory of "mysterious mansion-qi and fluids" to propose a novel therapeutic approach for KOA. Three core TCM treatment methods are introduced: using pungent-dispersing medicines to open mysterious mansion, eliminating dampness and unblocking collaterals to smooth mysterious mansion, and employing tonifying method to enhance mysterious mansion's function. By regulating the opening and closing of the Xuan Fu, it promotes the operation of Qi, blood and body fluids, and thus improves mitochondrial function. In this paper, from the perspective of mitochondrial quality control imbalance, the intrinsic connection between mitochondrial function and the theory of "mysterious mansion-qi and fluids" is explored in depth, so as to provide a more solid theoretical basis for the prevention and treatment of KOA. |
| Key words: knee osteoarthritis mitochondrial quality control mysterious mansion-qi and fluids chronic osteoarticular disease theoretical discussion |
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