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张淼, 徐淑颖, 徐海鹏, 孟祥瑞, 王丽娜, 张阳.基于“脾肾互赞”理论探讨内质网应激在多囊卵巢综合征中的作用[J].湖南中医药大学学报英文版,2025,45(5):939-944.[Click to copy
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| 基于“脾肾互赞”理论探讨内质网应激在多囊卵巢综合征中的作用 |
| 张淼,徐淑颖,徐海鹏,孟祥瑞,王丽娜,张阳 |
| (辽宁中医药大学第一临床学院, 辽宁 沈阳 110847;辽宁中医药大学附属医院, 辽宁 沈阳 110032) |
| 摘要: |
| 多囊卵巢综合征（PCOS）是一种常见的生殖内分泌系统疾病，其发病机制尚未完全明确。内质网应激（ERS）通过未折叠蛋白质应答信号通路参与PCOS的发生发展，与颗粒细胞凋亡、雄激素过多、慢性炎症及胰岛素抵抗等病理过程密切相关。ERS具有保护细胞与促细胞凋亡的双向作用，与中医“脾肾互赞”理论中二者在生理条件下维持机体健康及病理状态下互损导致机体损伤的机制具有相似性。脾肾亏虚可导致细胞内环境紊乱，从而诱发ERS，而ERS的持续激活又进一步加重PCOS的代谢与生殖功能障碍。本文从“脾肾互赞”理论出发，挖掘ERS在PCOS发病机制中的作用，以期研究二者联系，并探讨补肾健脾法调控ERS改善PCOS的作用机制，为PCOS的治疗提供新的思路和方法。 |
| 关键词: 脾肾互赞 多囊卵巢综合征 内质网应激 未折叠蛋白质应答 补肾健脾法 |
| DOI：10.3969/j.issn.1674-070X.2025.05.023 |
| Received:January 09, 2025 |
| 基金项目:辽宁省科技计划联合计划（2023JH2/101700220）；辽宁省教育厅2022高等学校基本科研项目（LJKZZ20220107）；沈阳市科学技术计划-公共卫生研发专项（沈科发〔2022〕14号）。 |
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| The role of endoplasmic reticulum stress in polycystic ovary syndrome based on the theory of "spleen-kidney mutual promotion" |
| ZHANG Miao, XU Shuying, XU Haipeng, MENG Xiangrui, WANG Li'na, ZHANG Yang |
| (The First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110032, China) |
| Abstract: |
| Polycystic ovary syndrome (PCOS) is a common reproductive endocrine system disease, and its pathogenesis is not completely clear. Endoplasmic reticulum stress (ERS) is involved in the occurrence and development of PCOS through the unfolded protein response signaling pathway, which is closely related to the pathological processes such as granulosa cell apoptosis, excessive androgen, chronic inflammation, and insulin resistance (IR). ERS exhibits a dual role in protecting cells and promoting apoptosis. It shares mechanistic similarities with the theory of "spleen-kidney mutual promotion" in Chinese medicine, wherein spleen and kidney synergistically maintain the body health under physiological conditions, yet lead to mutual damage and contribute to disease progression under pathological states. Spleen and kidney deficiency can lead to intracellular environment disorder, and thus induce ERS, the continuous activation of which further aggravates the metabolic and reproductive dysfunction of PCOS. Based on the theory of "spleen-kidney mutual promotion", this paper explores the role of ERS in the pathogenesis of PCOS, in order to find the relationship between the two, and to explore the mechanism by which the kidney-tonifying and spleen-strengthening therapeutic method alleviates PCOS through regulation of ERS, so as to provide new ideas and methods for the treatment of PCOS. |
| Key words: spleen-kidney mutual promotion polycystic ovary syndrome endoplasmic reticulum stress unfolded protein response tonifying kidney and strengthening spleen method |
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