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齐晓君, 孙启蒙, 李晓丽, 郝守江, 郝淑兰, 刘丽坤.刘丽坤教授从“伏毒致痹”探析奥沙利铂所致急性周围神经毒性[J].湖南中医药大学学报英文版,2025,45(5):910-915.[Click to copy
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| 刘丽坤教授从“伏毒致痹”探析奥沙利铂所致急性周围神经毒性 |
| 齐晓君,孙启蒙,李晓丽,郝守江,郝淑兰,刘丽坤 |
| (山西中医药大学, 山西 太原 030024;山西省中医药研究院, 山西 太原 030012) |
| 摘要: |
| 奥沙利铂是第三代铂类药，在消化道肿瘤中应用广泛，其不良反应以奥沙利铂所致周围神经毒性（OIPN）最为常见，分为急性和慢性两种。奥沙利铂所致急性周围神经毒性（AOIPN）是奥沙利铂输注后24～48 h内发生的短暂神经毒性症状，以感觉异常为主，影响患者生活质量，严重者被迫更换治疗方案，影响生存期。刘丽坤教授认为，伏毒是AOIPN的致病因素，其特点为痹阻脉络、藏匿性强，以温化寒湿、驱毒化瘀为治疗方法，并自拟温阳通络散，联合外洗，治疗效果显著。从“伏毒致痹”理论探讨AOIPN治疗，并附临床医案一则，以期为临床治疗AOIPN提供思路。 |
| 关键词: 奥沙利铂 周围神经病变 神经毒性 伏毒 温阳通络散 名医经验 |
| DOI：10.3969/j.issn.1674-070X.2025.05.018 |
| Received:December 08, 2024 |
| 基金项目:国家中医药管理局全国名老中医药专家传承工作室建设项目（国中医药人教函〔2022〕75号）；国家中医药传承创新中心建设单位（202203）；山西省卫生健康委员会医学科技创新团队建设任务（2020TD04）。 |
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| Professor LIU Likun's exploration of acute oxaliplatin-induced peripheral neurotoxicity from the perspective of "latent toxicity causing impediment" |
| QI Xiaojun, SUN Qimeng, LI Xiaoli, HAO Shoujiang, HAO Shulan, LIU Likun |
| (Shanxi University of Chinese Medicine, Taiyuan, Shanxi 030024, China;Shanxi Academy of Chinese Medicine, Taiyuan, Shanxi 030012, China) |
| Abstract: |
| Oxaliplatin is a third-generation platinum drug, which is widely used in digestive tract tumors, and its adverse reactions are most common in oxaliplatin-induced peripheral neurotoxicity (OIPN), which is classified into two types: acute and chronic. Acute oxaliplatin-induced peripheral neurotoxicity (AOIPN) is a transient neurotoxicity symptom occurring within 24-48 h after oxaliplatin infusion, which is dominated by sensory abnormalities that affects patients' quality of life, and in severe cases, forcing them to change their treatment regimen and affecting survival. Professor LIU Likun believes that hidden toxicity is the causative factor of AOIPN, which is characterized by impediment blocking vessels and collaterals and strong concealment, and it is treated by warming cold and dampness, expelling toxins and removing blood stasis, and the combination of external washing with the self-drafted Wenyang Tongluo Powder has a remarkable therapeutic effect. This paper discusses the treatment of AOIPN from the theory of "latent toxicity causing impediment", and attaches a clinical record in order to provide ideas for the clinical treatment of AOIPN. |
| Key words: oxaliplatin peripheral neuropathy neurotoxicity latent toxicity Wenyang Tongluo Powder experience of famous doctors |
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