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张昊, 郝学增.探讨益气泻肺汤酊剂经皮治疗对慢性心力衰竭气虚血瘀证患者的临床疗效[J].湖南中医药大学学报英文版,2025,45(5):891-897.[Click to copy
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| 探讨益气泻肺汤酊剂经皮治疗对慢性心力衰竭气虚血瘀证患者的临床疗效 |
| 张昊,郝学增 |
| (北京中医药大学, 北京 100029;北京中医药大学东直门医院, 北京 100007) |
| 摘要: |
| 目的 探讨益气泻肺汤酊剂经皮给药治疗慢性心力衰竭（CHF）气虚血瘀证患者的临床疗效及对生活质量的影响。方法 将2023年1月至2024年6月北京中医药大学东直门医院心血管内科收治的86例CHF气虚血瘀证患者采用随机数字表法分为试验组和对照组，每组43例。试验组采用常规CHF四联用药联合益气泻肺汤酊剂经皮外用治疗，对照组采用常规CHF四联用药联合安慰剂治疗，两组均干预14 d。比较两组治疗前后左室射血分数（LVEF）、血浆脑钠素（BNP）、中医证候积分、纽约心功能分级（NYHA）、6分钟步行试验（6MWT）、明尼苏达心力衰竭生存质量量表（MLHFQ）、匹兹堡睡眠质量指数（PSQI）的水平及安全性指标。结果 与治疗前相比，2组患者治疗后的LVEF水平、6MWT均提高（P＜0.05），BNP水平、中医证候各项积分及总分、PSQI评分及MLHFQ的总评分、躯体症状评分、心理负担评分均下降（P＜0.05）；与对照组比较，试验组在LVEF水平、6MWT均提高（P＜0.05），BNP水平、中医证候各项积分及总分、PSQI评分及MLHFQ的总评分、躯体症状评分、心理负担评分均下降（P＜0.05）。治疗后2组NYHA评分及安全性指标方面比较，差异无统计学意义（P＞0.05）。结论 益气泻肺汤酊剂经皮治疗可有效改善CHF气虚血瘀证患者心功能、临床症状及生活质量，其疗效优于单纯西药治疗。 |
| 关键词: 益气泻肺汤 慢性心力衰竭 经皮治疗 生活质量 6分钟步行试验 明尼苏达心力衰竭生存质量量表 纽约心功能分级 |
| DOI：10.3969/j.issn.1674-070X.2025.05.015 |
| Received:December 20, 2024 |
| 基金项目:首都临床特色诊疗技术研究及转化应用基金项目（Z221100007422095）。 |
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| Clinical efficacy of transdermal therapy of Yiqi Xiefei Decoction tincture on chronic heart failure patients with qi deficiency induced blood stasis pattern |
| ZHANG Hao, HAO Xuezeng |
| (Beijing University of Chinese Medicine, Beijing 100029, China;Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100007, China) |
| Abstract: |
| Objective To investigate the clinical efficacy of transdermal therapy of Yiqi Xiefei Decoction (YQXFD) tincture on chronic heart failure (CHF) patients with qi deficiency induced blood stasis pattern and its impact on their quality of life. Methods A total of 86 CHF patients with qi deficiency induced blood stasis pattern admitted to the Department of Cardiovascular Medicine of Dongzhimen Hospital, Beijing University of Chinese Medicine from January 2023 to June 2024 were divided into experimental group and control group using random number table method, with 43 patients in each group. The experimental group received conventional CHF quadruple medical therapy combined with transdermal YQXFD tincture, while the control group received conventional quadruple medical therapy combined with placebo. Both groups were treated continuously for 14 days. The levels of left ventricular ejection fraction (LVEF), plasma brain natriuretic peptide (BNP), TCM pattern scores, New York Heart Association (NYHA) Functional Classification, 6-minute walk test (6MWT) results, Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores, Pittsburgh Sleep Quality Index (PSQI) scores, and safety indicators were compared between the two groups before and after the treatment. Results After treatment, both groups showed significant improvements in LVEF and 6MWT compared with before treatment (P<0.05), while significant decreases were observed in BNP levels, individual and total TCM pattern scores, PSQI scores, and total MLHFQ scores, including physical symptom scores and psychological burden scores (P<0.05). Compared with the control group, the experimental group showed further significant improvements in LVEF and 6MWT (P<0.05), as well as significant decreases in BNP levels, individual and total TCM pattern scores, PSQI scores, and total MLHFQ scores, including physical symptom scores and psychological burden scores (P<0.05). After treatment, no statistically significant differences were found in NYHA scores and safety indicators between the two groups (P＞0.05). Conclusion Transdermal therapy of YQXFD tincture can effectively improve cardiac function, alleviate clinical symptoms, and enhance the quality of life of CHF patients with qi deficiency induced blood stasis pattern, with superior efficacy compared to western medicine therapy alone. |
| Key words: Yiqi Xiefei Decoction chronic heart failure transdermal therapy quality of life 6-minute walk test Minnesota Living with Heart Failure Questionnaire New York Heart Association Functional Classification |
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