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吉晓晓, 马宁, 崔霞, 张宁, 白雪, 李惠芳, 张瑞婧, 葛礼秀, 胡若冰.基于线粒体能量代谢障碍从脾肾-脑论治儿童孤独症谱系障碍[J].湖南中医药大学学报英文版,2025,45(3):486-490.[Click to copy
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| 基于线粒体能量代谢障碍从脾肾-脑论治儿童孤独症谱系障碍 |
| 吉晓晓,马宁,崔霞,张宁,白雪,李惠芳,张瑞婧,葛礼秀,胡若冰 |
| (北京中医药大学第三临床医学院, 北京 100029;北京中医药大学第三附属医院, 北京 100029) |
| 摘要: |
| 中医学认为，脾肾与脑在生理上相互依存、协同作用，病理上亦相互影响。肾藏精生髓，髓聚为脑，依赖于脾主运化，而脾主运化水谷精微，亦滋养脑髓。脾肾功能失调，脑失滋养，直接影响脑神经的发育和功能，与儿童孤独症谱系障碍密切相关。现代医学认为，线粒体是细胞内的“能量工厂”，负责产生ATP，为细胞提供能量。线粒体能量代谢障碍会导致细胞能量供应不足，影响神经元的正常功能和突触连接，进而可能引发儿童孤独症谱系障碍等神经发育障碍。因此，基于脾肾-脑理论，从“线粒体能量代谢障碍”角度，进一步探讨脾肾-脑与线粒体能量代谢的相关性，为儿童孤独症谱系障碍的临床防治提供新的理论依据与实践思路。 |
| 关键词: 孤独症谱系障碍 线粒体 能量代谢 脾肾 脑 |
| DOI：10.3969/j.issn.1674-070X.2025.03.014 |
| Received:October 23, 2024 |
| 基金项目:北京中医药大学一流学科建设项目（90010951310112）；第四批全国中医优秀人才研修项目（201724）。 |
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| Treatment of autism spectrum disorder in children based on mitochondrial energy metabolism disorders from the perspective of spleen/kidney-brain |
| JI Xiaoxiao, MA Ning, CUI Xia, ZHANG Ning, BAI Xue, LI Huifang, ZHANG Ruijing, GE Lixiu, HU Ruobing |
| (The Third Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100029, China;The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China) |
| Abstract: |
| Chinese medicine believes that the spleen/kidney and brain are interdependent and synergistic in physiology, and also influence each part in pathology. The kidney stores essence and generates marrow, which gathers to form the brain, relying on the spleen's function of transportation and transformation. The spleen transports and transforms the essence of food and water, which also nourishes the brain and marrow. Dysfunction of the spleen and kidney leads to a lack of nourishment for the brain, directly affecting the development and function of brain neurons, which is closely related to autism spectrum disorder (ASD) in children. Modern medicine considers mitochondria as the "energy factories" within cells, responsible for producing ATP to provide energy for cells. Disorders in mitochondrial energy metabolism can lead to insufficient energy supply for cells, affecting the normal function of neurons and synaptic connections, potentially causing neurodevelopmental disorders such as ASD in children. Therefore, based on the spleen/kidney-brain theory, further exploring the correlation between spleen/kidney-brain and mitochondrial energy metabolism from the perspective of "mitochondrial energy metabolism disorders" provides new theoretical foundations and practical approaches for the clinical prevention and treatment of ASD in children. |
| Key words: autism spectrum disorder mitochondria energy metabolism spleen and kidney brain |
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