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彭登发, 乐浩, 冯力, 李虎清, 徐佳.益肠散结方联合电针对结直肠癌术后患者胃肠功能和炎症因子水平的影响[J].湖南中医药大学学报英文版,2025,45(3):474-479.[Click to copy
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| 益肠散结方联合电针对结直肠癌术后患者胃肠功能和炎症因子水平的影响 |
| 彭登发,乐浩,冯力,李虎清,徐佳 |
| (恩施土家族苗族自治州中心医院中医部外一科, 湖北 恩施 445000;恩施土家族苗族自治州中心医院西医部口腔科, 湖北 恩施 445000) |
| 摘要: |
| 目的 探讨益肠散结方联合电针对结直肠癌术后患者胃肠功能和炎症因子水平的影响。方法 选取2021年1月至2021年12月期间湖北恩施土家族苗族自治州中心医院收治的80例腹腔镜结直肠癌根治术患者作为研究对象，回顾分析入组者临床资料，以不同治疗方式分为对照组与观察组，各40例。对照组患者术后给予电针治疗，观察组患者在对照组的基础上增加益肠散结方治疗，比较两组患者的胃肠功能、炎症因子水平、中医证候积分、卡氏功能量表（KPS）评分及2年期间无病生存率。结果 与对照组比较，观察组首次排气、首次排便、肠鸣音恢复及恢复进食时间更短（P<0.05）。两组治疗1周及8周后，肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、白细胞介素-6（IL-6）水平均低于治疗前（P<0.05），且观察组低于对照组（P<0.05）。治疗8周后，两组中医证候积分较治疗前均降低，KPS评分较治疗前均升高（P<0.05）；且观察组中医证候积分低于对照组，KPS评分高于对照组（P<0.05）。观察组随访2年期间无病生存率高于对照组（P<0.05）。结论 益肠散结方联合电针治疗可促进结直肠癌术后患者胃肠功能恢复，改善其临床症状，减轻机体炎症水平，提高其生活质量，延长其无病生存期。 |
| 关键词: 结直肠癌 益肠散结方 电针 胃肠功能 炎症因子 无病生存率 |
| DOI：10.3969/j.issn.1674-070X.2025.03.012 |
| Received:August 20, 2024 |
| 基金项目:湖北省中医药管理局中医药科研项目（ZY2023F119）。 |
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| Effects of Yichang Sanjie Formula combined with electroacupuncture on gastrointestinal function and inflammatory factor levels in postoperative patients with colorectal cancer |
| PENG Dengfa, YUE Hao, FENG Li, LI Huqing, XU Jia |
| (Department of SurgeryⅠ, Chinese Medicine Division, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei 445000, China;Department of Stomatology, Western Medicine Division, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei 445000, China) |
| Abstract: |
| Objective To explore the effects of Yichang Sanjie Formula (YCSJF) combined with electroacupuncture on gastrointestinal function and inflammatory factor levels in postoperative patients with colorectal cancer. Methods Eighty patients who underwent laparoscopic radical resection for colorectal cancer at the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture in Hubei Province from January 2021 to December 2021 were selected as the study subjects. The clinical data of the enrolled patients were retrospectively analyzed, and they were divided into a control group and an observation group, with 40 patients in each, based on different treatment methods. Patients in the control group received electroacupuncture therapy after surgery, while patients in the observation group were givenYCSJF in addition to the treatment received by the control group. The gastrointestinal function, inflammatory factor levels, Chinese medicine pattern scores, Karnofsky Function Scale (KPS) scores, and two-year disease-free survival rate were compared between the two groups of patients. Results Compared with the control group, the observation group had shorter times to first flatulence, first defecation, recovery of bowel sounds, and resumption of feeding (P<0.05). After one week and eight weeks of treatment, the levels of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin-6 (IL-6) were lower in both groups compared to before treatment (P<0.05), and the levels were lower in the observation group than those in the control group (P<0.05). After eight weeks of treatment, the Chinese medicine pattern scores of both groups decreased compared to before treatment, while the KPS scores increased compared to before treatment (P<0.05); moreover, the Chinese medicine pattern scores were lower and the KPS scores were higher in the observation group than those in the control group (P<0.05). The disease-free survival rate of the observation group was higher than that of the control group during the two-year follow-up period (P<0.05). Conclusion The combination of YCSJF and electroacupuncture can promote gastrointestinal function recovery, relieve clinical symptoms, reduce inflammation levels, improve quality of life, and prolong disease-free survival in postoperative patients with colorectal cancer. |
| Key words: colorectal cancer Yichang Sanjie Formula electroacupuncture gastrointestinal function inflammatory factors disease-free survival rate |
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