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张轩, 隋楠.中医药调控短链脂肪酸治疗功能性便秘研究进展[J].湖南中医药大学学报英文版,2025,45(1):169-175.[Click to copy
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| This paper
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| 中医药调控短链脂肪酸治疗功能性便秘研究进展 |
| 张轩,隋楠 |
| (辽宁中医药大学, 辽宁 沈阳 110847;辽宁中医药大学附属第三医院, 辽宁 沈阳 110003) |
| 摘要: |
| 功能性便秘是一种常见的胃肠道疾病，会给患者带来诸多不适和困扰。短链脂肪酸作为一种重要的肠道菌群代谢产物，在肠道中扮演着重要的角色，对肠道健康、免疫系统、营养吸收等方面都具有重要影响，与功能性便秘的发生发展有着密切联系。近年来，中医药治疗功能性便秘的机制备受关注，通过综述相关文献，总结短链脂肪酸在调节肠道蠕动、促进粪便排泄等方面的作用机制，探讨其在中医药治疗功能性便秘中的应用前景，以期为临床进一步应用中医药治疗功能性便秘提供理论依据。 |
| 关键词: 功能性便秘 短链脂肪酸 中医药 肠道菌群 信号通路 |
| DOI：10.3969/j.issn.1674-070X.2025.01.028 |
| Received:April 28, 2024 |
| 基金项目:国家自然科学基金面上项目(82174370)。 |
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| Research progress on the treatment of functional constipation by regulating short-chain fatty acids with Chinese medicine |
| ZHANG Xuan, SUI Nan |
| (Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, China;The Third Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110003, China) |
| Abstract: |
| Functional constipation is a common gastrointestinal disease that causes many discomforts and troubles for patients. Short-chain fatty acids, important metabolites produced by gut microbiota, play a crucial role in the intestine, exerting significant influences on intestinal health, the immune system, nutrient absorption, and other aspects. They are closely related to the occurrence and development of functional constipation. In recent years, the mechanism of Chinese medicine in treating functional constipation has received much attention. By reviewing relevant literature, this paper summarizes the mechanism of short-chain fatty acids in regulating intestinal peristalsis and promoting fecal excretion, and explores their application prospects in the treatment of functional constipation with Chinese medicine, in order to provide a theoretical basis for further clinical application of Chinese medicine in treating functional constipation. |
| Key words: functional constipation short-chain fatty acids Chinese medicine gut microbiota signaling pathway |
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