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汪艳丽, 任甜甜, 刘金凤, 关宣可, 常兴, 吴巧敏, 刘志明, 刘如秀.补肾活血方治疗老年缓慢性心律失常随机对照研究[J].湖南中医药大学学报英文版,2024,44(10):1816-1821.[Click to copy
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| 补肾活血方治疗老年缓慢性心律失常随机对照研究 |
| 汪艳丽,任甜甜,刘金凤,关宣可,常兴,吴巧敏,刘志明,刘如秀 |
| (中国中医科学院广安门医院心血管科, 北京 10053) |
| 摘要: |
| 目的 观察补肾活血方对老年缓慢性心律失常肾虚血瘀证患者的临床疗效及安全性。方法 选取就诊于中国中医科学院广安门医院心血管科门诊及病房的63例老年缓慢性心律失常患者，按照随机数字表法分为治疗组32例和对照组31例。治疗组予补肾活血方，200 mL/次，2次/d；对照组予参松养心胶囊，3粒/次，3次/d。两组患者疗程均为4周。对比两组患者中医证侯积分、临床疗效、24小时动态心电图、常规心电图、心功能、生活质量评分及安全性指标。结果 与对照组比较，治疗组中医证候总积分，心悸、胸闷、畏寒肢冷、头晕耳鸣等单项证候积分均降低（P＜0.05）；24小时动态心电图总心率、平均心率及最慢心率均升高（P＜0.05，P＜0.01）；生理和社会功能等方面生活质量评分升高（P＜0.05）。在临床疗效、常规心电图及心功能方面，治疗组与对照组相比无统计学意义（P＞0.05）。结论 补肾活血方治疗老年缓慢性心律失常肾虚血瘀证患者具有良好的临床疗效及安全性。 |
| 关键词: 补肾活血方 老年缓慢性心律失常 肾虚血瘀证 动态心电图 心功能 |
| DOI：10.3969/j.issn.1674-070X.2024.10.014 |
| Received:May 24, 2024 |
| 基金项目:国家自然科学基金项目(81904045);中央高水平中医医院临床科研业务κ助:基于名老中医经验的院内制剂项目(HLCMHPP2023053);北京中医药薪火传承"新3+3"工程刘志明门人(刘如秀)传承工作站(2023-SZ-G-02);北京中医药薪火传承"新3+3"工程刘志明"三名"传承工作室(2023-SZ-F-06);中国中医科学院学部委员学术传承与传播专项项κ助:学部委员刘志明学术经验传承、创新、传播、推动中医发展(CI2022E012XB);中国中医科学院基本科研业务费优秀青年科技人才培养专项(ZZ14-YQ-014);中国中医科学院所级课题创新培育项目(2016S361)。 |
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| Randomized controlled study of Bushen Huoxue Formula in treating senile bradyarrhythmia |
| WANG Yanli, REN Tiantian, LIU Jinfeng, GUAN Xuanke, CHANG Xing, WU Qiaomin, LIU Zhiming, LIU Ruxiu |
| (Cardiovascular Department of Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China) |
| Abstract: |
| Objective To observe the clinical efficacy and safety of Bushen Huoxue Formula (BSHXF) on senile bradyarrhythmia of kidney deficiency and blood stasis pattern. Methods Sixty-three elderly patients with bradyarrhythmia were selected from the outpatient and wards of the Cardiovascular Department of Guang'anmen Hospital, China Academy of Chinese Medical Sciences. They were divided into treatment group (32 cases) and control group (31 cases) according to the random number table. The treatment group was given BSHXF, 200 mL per bag/times, 2 times/d, while the control group was given Shensong Yangxin Capsule, 3 capsules/times, 3 times/d. Both groups were treated for four weeks. The TCM pattern score, 24-hour dynamic electrocardiogram (ECG), routine ECG, cardiac function, life quality score, and safety indicators were compared between the two groups. Results Compared with the control group, the total TCM pattern scores and individual pattern scores such as palpitation, chest tightness, aversion to cold with cold limbs, dizziness, and tinnitus were reduced in the treatment group (P<0.05). The total heart rate, average heart rate, and slowest heart rate of 24-hour dynamic ECG increased (P<0.05, P<0.01), and the life quality scores in terms of physiological and social functions increased (P<0.05). In terms of routine ECG and cardiac function, there was no statistically significant difference between the treatment group and the control group (P>0.05). Conclusion BSHXF has good clinical efficacy and safety in treating senile bradyarrhythmia of kidney deficiency and blood stasis pattern. |
| Key words: Bushen Huoxue Formula senile bradyarrhythmia kidney deficiency and blood stasis pattern dynamic electrocardiogram cardiac function |
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