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伍紫炫, 彭俊, 江冰, 黄建三, 彭清华.灯盏细辛防治青光眼的研究进展[J].湖南中医药大学学报英文版,2024,44(9):1708-1714.[Click to copy
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| 灯盏细辛防治青光眼的研究进展 |
| 伍紫炫,彭俊,江冰,黄建三,彭清华 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007;中南大学湘雅二医院, 湖南 长沙 410006;湖南湘雅制药股份有限公司, 湖南 长沙 410013) |
| 摘要: |
| 青光眼是一种与眼内压升高密切相关的眼科疾病，其病理过程导致视神经受损和视力减退。全球范围内，青光眼的患病率持续上升，成为公共卫生领域的重要挑战。尽管现代医学在青光眼防治方面取得了一定进展，但当前治疗手段对于病程的改变尚未达到理想水平。灯盏细辛是一种传统中药，其主要有效成分为灯盏花乙素和总咖啡酸酯，对青光眼的治疗具有潜在价值。现代药理学研究揭示，灯盏细辛通过降低眼压、改善眼部血流和调节免疫反应等途径，改善视网膜微环境、促进视网膜神经节细胞生长并减轻其损伤。探讨灯盏细辛主要成分对青光眼的干预机制，为青光眼的预防和治疗提供科学依据。 |
| 关键词: 青光眼 灯盏细辛 眼压 视网膜微环境 中药应用 作用机制 |
| DOI：10.3969/j.issn.1674-070X.2024.09.025 |
| Received:January 19, 2024 |
| 基金项目:国家自然科学基金面上项目（82274588，81874492）；湖南中医药大学揭榜挂帅科研项目（2022XJJB003）；湖南省中医药科研计划项目（D2022045）。 |
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| Research progress on the prevention and treatment of glaucoma with Erigerontis Herba |
| WU Zixuan, PENG Jun, JIANG Bing, HUANG Jiansan, PENG Qinghua |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;The Second Xiangya Hospital of Central South University, Changsha, Hunan 410006, China;Hunan Xiangya Pharmaceutical Co., LTD., Changsha, Hunan 410013, China) |
| Abstract: |
| Glaucoma is an ophthalmic disease closely associated with elevated intraocular pressure, leading to optic nerve damage and vision loss. The prevalence of glaucoma continues to rise globally, posing a significant challenge to public health. Although modern medicine has made certain progress in the prevention and treatment of glaucoma, current therapeutic approaches have not yet achieved optimal outcomes in altering the disease course. Erigerontis Herba, a traditional Chinese medicine, holds potential therapeutic value for glaucoma, primarily due to its active ingredients, scutellarin and total caffeic acid esters. Modern pharmacological research has revealed that Erigerontis Herba aids in glaucoma treatment by lowering intraocular pressure, improving ocular blood flow, and modulating immune responses. These mechanisms contribute to the enhancement of the retinal microenvironment, protection of retinal ganglion cell growth, and reduction of their damage. This paper aims to explore the mechanisms by which the major components of Erigerontis Herba intervene in glaucoma, providing a scientific basis for its prevention and treatment. |
| Key words: glaucoma Erigerontis Herba intraocular pressure retinal microenvironment application of Chinese medicines mechanism of action |
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