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宋晓玲, 刘宁, 李玲, 向丽萍, 田毅, 刘文, 袁婉婧.紫龙膏联合LED红光对慢性难愈性创面愈合及TGF-β与PDGF的影响[J].湖南中医药大学学报英文版,2024,44(9):1653-1659.[Click to copy
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| 紫龙膏联合LED红光对慢性难愈性创面愈合及TGF-β与PDGF的影响 |
| 宋晓玲,刘宁,李玲,向丽萍,田毅,刘文,袁婉婧 |
| (湖南中医药大学第二附属医院, 湖南 长沙 410005;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 探讨紫龙膏联合LED红光促进慢性难愈性创面的愈合情况以及对转化生长因子-β（transforming growth fator-β, TGF-β）和血小板源性生长因子（platelet-derived growth factor, PDGF）的影响。方法 选取2022年1月至2023年1月湖南中医药大学第二附属医院收治的48例慢性难愈性创面患者，按随机数字表法分为对照组、LED组、紫龙膏组、紫龙膏+LED组，每组12例，连续干预28 d。计算各组创面愈合率；比较各组临床疗效；HE染色观察各组创面组织病理变化；免疫组织化学检测各组PDGF蛋白表达水平；Western blot检测各组TGF-β蛋白表达水平。结果 紫龙膏组（100.00%）、紫龙膏+LED组（100.00%）临床有效率高于LED组（83.33%）、对照组（25.00%）（P＜0.01）。与第14天比较，第28天紫龙膏组和紫龙膏+LED组的创面愈合率和PDGF、TGF-β蛋白表达水平均升高（P＜0.05，P＜0.01）。与对照组、LED组比较，第14、28天紫龙膏组和紫龙膏+LED组的创面愈合率和PDGF、TGF-β蛋白表达水平均升高（P＜0.05，P＜0.01）。与紫龙膏组比较，紫龙膏+LED组第14天的创面愈合率和TGF-β蛋白表达水平升高（P＜0.05，P＜0.01），第28天的创面愈合率和PDGF、TGF-β蛋白表达水平均升高（P＜0.05）。结论 紫龙膏联合LED红光治疗慢性难愈性创面的效果较好，其可能通过提高TGF-β与PDGF蛋白表达水平，促进创面毛细血管增生与成纤维细胞增生，从而加速创面的愈合。 |
| 关键词: 慢性难愈性创面 紫龙膏 LED红光 转化生长因子-β 血小板源性生长因子 |
| DOI：10.3969/j.issn.1674-070X.2024.09.015 |
| Received:May 29, 2024 |
| 基金项目:湖南省中医药科研基金项目（B2023130）；湖南中医药大学校级科研基金项目（2021XJJJ059）。 |
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| Effects of Zilong Ointment combined with LED red light on the healing of refractory ulcer wounds, TGF-β, and PDGF |
| SONG Xiaoling, LIU Ning, LI Ling, XIANG Liping, TIAN Yi, LIU Wen, YUAN Wanjing |
| (The Second Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To investigate the effects of Zilong Ointment combined with LED red light on the healing of refractory ulcer wounds and on the transforming growth factor of transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF). Methods Forty-eight patients with refractory ulcer wounds admitted to the Second Hospital of Hunan University of Chinese Medicine from January 2022 to January 2023 were divided into control group, LED group, Zilong Ointment group, and Zilong Ointment+LED group according to the random table number method, with 12 patients in each group. Continuous intervention was administered for 28 days. The wound healing rate was calculated and clinical efficacy was compared in each group. The pathological changes of wound tissue of each group were observed by HE staining. The expression level of PDGF protein in each group was determined by immunohistochemistry. The expression level of TGF-β protein in each group was checked by Western blot. Results The clinical effective rate of Zilong Ointment group (100.00%) and Zilong Ointment+LED group (100.00%) was higher than that of LED group (83.33%) and control group (25.00%) (P＜0.05, P＜0.01). Compared with those of the 14th day, the wound healing rate and the protein expression levels of PDGF and TGF-β in the Zilong Ointment group and Zilong Ointment+LED group were significantly increased on the 28th day (P＜0.01). Compared with those of the control group and LED group, the wound healing rate, the protein expression levels of PDGF and TGF-β in Zilong Ointment group and Zilong Ointment+LED group were higher on the 14th and 28th day (P＜0.05, P＜0.01). Compared with those of Zilong Ointment Group, the wound healing rate and TGF-β protein expression level of Zilong Ointment+LED group were significantly elevated on both the 14th and 28th day (P＜0.05, P＜0.01). Conclusion Zilong Ointment combined with LED red light therapy has a good effect on chronic refractory ulcer wounds, which may promote wound capillary and fibroblast proliferation by increasing the protein expression levels of TGF-β and PDGF, thereby accelerating the wound healing. |
| Key words: refractory ulcer wound Zilong Ointment LED red light platelet-derived growth factor transforming growth factor-β |
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