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陈江, 潘渴, 凌云, 张冲, 吴曾涵, 邝高艳, 邝涛.加味独活寄生合剂联合体外冲击波对腰椎间盘突出症患者的临床疗效及其对NF-κB信号通路的影响[J].湖南中医药大学学报英文版,2024,44(8):1510-1516.[Click to copy
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| 加味独活寄生合剂联合体外冲击波对腰椎间盘突出症患者的临床疗效及其对NF-κB信号通路的影响 |
| 陈江,潘渴,凌云,张冲,吴曾涵,邝高艳,邝涛 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察加味独活寄生合剂联合体外冲击波对寒湿痹阳型腰椎间盘突出症的临床疗效，及对NF-κB信号通路的影响。方法 将湖南中医药大学第一附属医院68例寒湿痹阻型腰椎间盘突出症患者按入组顺序随机分为试验组与对照组，每组34例。对照组予体外冲击波治疗，试验组在体外冲击波的基础上给予加味独活寄生合剂治疗，两组均治疗2周。采用疼痛视觉模拟（visualanalogue scale, VAS）评分、Oswestry功能量化指数（oswestry disability index, ODI）评分及日本骨科协会评分（Japanese orthopaedic association, JOA）评估两组患者的疗效；用ELISA检测治疗前后血清NF-κB信号通路指标（p50、p65）、白细胞介素-8（Interleukin-8, IL-8）、白细胞介素-10（Interleukin-10, IL-10）、肿瘤坏死因子-α（Tumor Necrosis Factor-alpha, TNF-α）表达含量。结果 治疗后，两组患者NF-κB信号通路指标（p50、p65）、IL-8、TNF-α与治疗前比较均降低（P＜0.01），IL-10明显升高（P＜0.01）。治疗后，两组患者JOA评分、ODI评分与治疗前比较均显著改善（P＜0.01）；且试验组效果优于对照组（P＜0.01）。两组患者VAS评分差异无统计学意义（P＞0.05）。结论 加味独活寄生合剂联合体外冲击波治疗腰椎间盘突出症可能通过抑制NF-κB信号通路的激活从而影响下游炎症因子表达，减轻LDH患者异常炎症反应，改善腰椎功能。 |
| 关键词: 腰椎间盘突出症 加味独活寄生合剂 体外冲击波 临床疗效 NF-κB信号通路 |
| DOI：10.3969/j.issn.1674-070X.2024.08.023 |
| Received:April 12, 2024 |
| 基金项目:湖南省中医药管理局重点项目基金（C2022022）；湖南中医药大学中医学一流学科建设课题（2021ZYX16）；伤科青年医师创新发展项目（GSKQNJJ-2023-019）。 |
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| Clinical efficacy of Jiawei Duhuo Jisheng Mixture combined with extracorporeal shock wave therapy on patients with lumbar disc herniation and its effects on NF-κB signaling pathway |
| CHEN Jiang, PAN Ke, LING Yun, ZHANG Chong, WU Zenghan, KUANG Gaoyan, KUANG Tao |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the clinical efficacy of Jiawei Duhuo Jisheng Mixture (JWDHJSM) combined with extracorp-oreal shock wave therapy (ESWT) on lumbar disc herniation (LDH) of cold dampness impediment pattern, as well as its effects on NF-κB signaling pathway. Methods Sixty-eight LDH patients with cold-dampness impediment pattern in the First Hospital of Hunan University of Chinese Medicine were randomly divided into experimental group and control group according to the order of enrollment, with 34 cases in each group. The control group was treated with ESWT, while the experimental group was treated with JWDHJSM on the basis of ESWT. Both groups were treated for two weeks. The visual analogue scale (VAS) scores, Oswestry Disability Index (ODI) scores, and Japanese Orthopaedic Association (JOA) scores were used to evaluate the efficacy of the two groups. ELISA was used to examine the expression levels of serum NF-κB signaling pathway indicators (p50, p65), interleukin-8 (IL-8), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α) before and after treatment. Results After treatment, the levels of NF-κB signaling pathway indicators (p50, p65), IL-8, and TNF-α in both groups were lower than those before treatment (P＜0.01), while IL-10 increased significantly (P＜0.01). The JOA scores and ODI scores of both groups were significantly improved compared with those before treatment (P＜0.01), and the effects of experimental group were better than those of the control group (P＜0.01). There was no significant difference in VAS scores between the two groups (P＞0.05). Conclusion JWDHJSM combined with ESWT for LDH may affect the expression of downstream inflammatory factors by inhibiting the activation of NF-κB signaling pathway, thereby reducing abnormal inflammatory responses of LDH patients and improving lumbar function. |
| Key words: lumbar disc herniation Jiawei Duhuo Jisheng Mixture extracorporeal shock wave therapy clinical efficacy NF-κB signaling pathway |
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