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倪伟, 钟润琪, 陈海交, 张健, 李硕, 廖焦鲁.基于肠道菌群探析针刺通调阳明治疗血管性痴呆的机制[J].湖南中医药大学学报英文版,2024,44(7):1292-1297.[Click to copy
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| 基于肠道菌群探析针刺通调阳明治疗血管性痴呆的机制 |
| 倪伟,钟润琪,陈海交,张健,李硕,廖焦鲁 |
| (中南大学湘雅医院, 湖南 长沙 410008;中南大学湘雅医院国家老年疾病临床医学研究中心, 湖南 长沙 410008;湖南中医药大学湘杏学院, 湖南 岳阳 414615;重庆市中医院, 重庆 400021) |
| 摘要: |
| 血管性痴呆继发于脑血管疾病，目前已成为老年痴呆的主要类型之一。肠道菌群借助肠-脑轴通过神经、免疫、内分泌和代谢等多种途径实现与大脑之间的双向调控，从而对痴呆等中枢神经退行性病变产生重要影响。中医之阳明与肠道菌群及血管性痴呆在生理、病理方面存在诸多共通之处。从阳明入手，通过调节肠道菌群治疗血管性痴呆成为新的突破点。以肠道菌群为基点，阐释针刺通调阳明治疗血管性痴呆的内涵机制，以期为其临床防治提供新的视角和方法。 |
| 关键词: 血管性痴呆 肠道菌群 阳明 针刺 机制 |
| DOI：10.3969/j.issn.1674-070X.2024.07.021 |
| Received:January 27, 2024 |
| 基金项目:湖南省中医药科研计划项目（D2022051）。 |
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| Mechanism of unblocking and regulating yangming by acupuncture for vascular dementia based on intestinal flora |
| NI Wei, ZHONG Runqi, CHEN Haijiao, ZHANG Jian, LI Shuo, LIAO Jiaolu |
| (Xiangya Hospital of Central South University, Changsha, Hunan 410008, China;National Clinical Medical Research Center for Geriatric Diseases, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China;Xiangxing College, Hunan University of Chinese Medicine, Yueyang, Hunan 414615, China;Chongqing Hospital of Chinese Medicine, Chongqing 400021, China) |
| Abstract: |
| Vascular dementia (VD), secondary to cerebrovascular disease, has become one of the main types of senile dementia. With the help of the gut-brain axis, intestinal flora can achieve bidirectional regulation with the brain through neurological immune, endocrine and metabolic and other ways, thus exerting an important influence on central neurodegenerative diseases such as dementia. Yangming of TCM shares many commonalities (including the large intestine and stomach as well as their corresponding meridians) with intestinal flora and VD in both physiological and pathological aspects. Hence, from the point of yangming, the treatment of VD by regulating intestinal flora has become a new breakthrough point. Based on intestinal flora, the intrinsic mechanism of unblocking and regulating yangming by acupuncture in VD treatment has been explained in order to provide new perspectives and methods for the clinical prevention and treatment of VD. |
| Key words: vascular dementia intestinal flora yangming acupuncture mechanism |
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