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余湘浩, 何华, 王晓雯.百合地黄汤治疗失眠伴抑郁焦虑的药理机制与临床应用研究进展[J].湖南中医药大学学报英文版,2024,44(6):1133-1139.[Click to copy
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| 百合地黄汤治疗失眠伴抑郁焦虑的药理机制与临床应用研究进展 |
| 余湘浩,何华,王晓雯 |
| (河南中医药大学第二临床医学院, 河南 郑州 450003;河南省中医院, 河南 郑州 450002) |
| 摘要: |
| 失眠伴抑郁焦虑的发病率逐年上升，严重困扰人们的正常学习和生活。失眠、抑郁和焦虑既可以独立发生，也可以相伴存在，在症状和疾病的层面密不可分。单胺类神经递质改变、下丘脑-垂体-肾上腺轴功能失调、神经可塑性损伤、免疫细胞炎性因子激活及脑源性营养因子合成减少等是失眠伴抑郁焦虑发生的共性因素。中医学认为本病核心病机为肝经郁热、阴血不足，与心、肾、脾三脏相关。经典名方百合地黄汤具有养阴清热之功，临床治疗失眠伴抑郁焦虑疗效显著。从研究概况、药理机制、临床疗效等多方面综述近年来百合地黄汤治疗失眠伴抑郁焦虑的研究进展，为失眠伴抑郁焦虑的治疗提供新方法，同时也为现代临床研究与经典名方应用提供新思路。 |
| 关键词: 百合地黄汤 失眠 抑郁 焦虑 药理 作用机制 |
| DOI：10.3969/j.issn.1674-070X.2024.06.029 |
| Received:January 16, 2024 |
| 基金项目:全国名老中医药专家传承工作室建设项目（国中医药人教函〔２０２２〕75号）。 |
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| Research progress on pharmacological mechanism and clinical application of Baihe Dihuang Decoction in treating insomnia with depression and anxiety |
| YU Xianghao, HE Hua, WANG Xiaowen |
| (The Second Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan 450003, China;Henan Province Hospital of TCM, Zhengzhou, Henan 450002, China) |
| Abstract: |
| The incidence of insomnia with depression and anxiety is increasing year by year, which seriously disturbs people's normal study and life. Insomnia, depression, and anxiety can occur independently or coexist, and they are inseparable at the level of symptomatology and disease. Common factors of insomnia with depression and anxiety include the changes in monoamine neurotransmitters, dysfunction of hypothalamic-pituitary-adrenal (HPA) axis, neuroplasticity impairment, activation of inflammatory factors of immune cells, and decreased synthesis of brain-derived growth factor (BDNF). Chinese medicine believes that the core pathogenesis of this disease is heat stagnation in the liver meridian and yin-blood deficiency, which is related to the three viscera of the heart, kidney, and spleen. The famous classical formula Baihe Dihuang Decoction (BHDHD) has the function of nourishing yin and clearing heat, showing remarkable clinical efficacy in treating insomnia with depression and anxiety. This paper summarizes the research progress of BHDHD in treating insomnia with depression and anxiety in recent years from the aspects of research overview, pharmacological mechanism, and clinical efficacy, which provides new methods for the treatment of insomnia with depression and anxiety, as well as new ideas for modern clinical research and the application of famous classical formulas. |
| Key words: Baihe Dihuang Decoction insomnia depression anxiety pharmacology mechanism of action |
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