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蒋昕, 潘志, 王颖航.基于Th17/Treg平衡对类风湿关节炎作用机制的研究概况[J].湖南中医药大学学报英文版,2024,44(6):1117-1123.[Click to copy
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| 基于Th17/Treg平衡对类风湿关节炎作用机制的研究概况 |
| 蒋昕,潘志,王颖航 |
| (长春中医药大学, 吉林 长春 130117;长春中医药大学附属医院, 吉林 长春 130021) |
| 摘要: |
| 类风湿关节炎（rheumatoid arthritis, RA）是全身性、持续性、自身免疫性疾病，其病理机制涉及多种免疫细胞，尤其是T淋巴细胞。辅助性T细胞17（relper T cell 17, Th17）和调节性T细胞（regulatory T cell, Treg）是构成免疫系统的关键元素，在维持免疫稳态方面起着重要的作用。对单味中药及其有效成分、中药复方、中成药基于Th17/Treg平衡治疗RA的研究进展进行概括，为RA的临床治疗提供理论指导，为了解RA的发病机制提供新的思路。 |
| 关键词: 类风湿关节炎 辅助性T细胞17 调节性T细胞 单味中药 中药复方 中成药 |
| DOI：10.3969/j.issn.1674-070X.2024.06.027 |
| Received:January 15, 2024 |
| 基金项目:国家自然科学基金项目（82074324）；吉林省科技厅项目（20210101235JC）。 |
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| Review on the mechanism of action of rheumatoid arthritis based on Th17/Treg balance |
| JIANG Xin, PAN Zhi, WANG Yinghang |
| (Changchun University of Chinese Medicine, Changchun, Jilin 130117, China;Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, China) |
| Abstract: |
| Rheumatoid arthritis (RA) is a systemic, persistent, and autoimmune disease, and its pathological mechanism involves a variety of immune cells, especially T lymphocytes. Helper T cells 17 (Th17) and regulatory T cells (Treg) are the key elements to construct immune system and play an important role in maintaining immune homeostasis. This paper summarizes the research progress of single Chinese medicine and its active ingredients, Chinese medicine compounds, and Chinese patent medicine in treating RA based on Th17/Treg balance, providing theoretical guidance for the clinical treatment of RA and new ideas for understanding the pathogenesis of RA. |
| Key words: rheumatoid arthritis helper T cells 17 regulatory T cells single Chinese medicine Chinese medicine compound Chinese patent medicine |
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