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董凤怡, 高宗跃, 周晓丽, 杨娅娟, 王炎炎, 刘一帆, 莫凡, 吴婧.从脾论治溃疡性结肠炎浅析[J].湖南中医药大学学报英文版,2024,44(5):857-862.[Click to copy
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| 从脾论治溃疡性结肠炎浅析 |
| 董凤怡,高宗跃,周晓丽,杨娅娟,王炎炎,刘一帆,莫凡,吴婧 |
| (河南中医药大学第二临床医学院, 河南 郑州 450002;河南省中医院, 河南 郑州 450002;河南中医药大学第三附属医院, 河南 郑州 450008) |
| 摘要: |
| 溃疡性结肠炎（ulcerative colitis，UC）是临床常见但发病机制尚未明确的炎性肠道疾病之一，发病率高，且易复发，其发病机制、诊断和治疗是目前医学研究的热点。中医学多认为脾虚是UC的根本病机，脾虚失运，升降失司，易成泄泻。因此，以脾为本，从脾论治是治疗UC的关键。现代研究发现，运用从脾论治理念治疗UC时，可通过维持肠道菌群稳态、调节线粒体代谢及调节肠道免疫功能平衡，影响UC的发生发展。探讨从脾论治在UC中的作用，依据从脾论治UC的相关机制，将健脾作为从脾论治UC的核心，配合燥湿、疏肝和温肾等治法，以期为有效治疗UC提供新的诊疗角度和治疗思路。 |
| 关键词: 溃疡性结肠炎 从脾论治 肠道菌群 线粒体 免疫功能 治则治法 |
| DOI：10.3969/j.issn.1674－070X.2024.05.020 |
| Received:December 28, 2023 |
| 基金项目:河南省中医药科学研究专项课题项目（2022ZY2027，2023ZY2103）。 |
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| Brief analysis of treating ulcerative colitis from the spleen |
| DONG Fengyi, GAO Zongyue, ZHOU Xiaoli, YANG Yajuan, WANG Yanyan, LIU Yifan, MO Fan, WU Jing |
| (The Second Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan 450002, China;Henan Provincial Hospital of TCM, Zhengzhou, Henan 450002, China;The Third Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450008, China) |
| Abstract: |
| Clinically, ulcerative colitis (UC) is one of the common inflammatory intestinal diseases with unclear pathogenesis, high morbidity, and easy recurrence. Its pathogenesis, diagnosis, and treatment are currently hot spots in medical research. TCM holds that spleen deficiency is the fundamental pathogenesis of UC, resulting in dysfunction in transportation, thus further leading to loss of control over ascending and descending of qi, which is prone to diarrhea. Therefore, taking the spleen as the foundation and treating UC from the spleen is the key to treatment. Modern research has found that treating UC from the spleen can affect the occurrence and development of UC by maintaining the homeostasis of intestinal flora, regulating mitochondrial metabolism, and balancing intestinal immune function. Thus, based on the relevant mechanisms of treating UC from the spleen, this article aims to explore the role of treating UC from the spleen, taking strengthening the spleen as the core, combined with other treatment methods such as drying dampness, soothing the liver, and warming the kidney, hoping to provide new diagnostic perspectives and therapeutic ideas for effective treatment of UC. |
| Key words: ulcerative colitis treatment from the spleen intestinal flora mitochondrion immune function treatment principles and methods |
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