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智慧,冯祥,曾理,李武,李江山.催产素与孤独症谱系障碍的发病关系及推拿干预效应的理论探索[J].湖南中医药大学学报英文版,2024,44(4):617-622.[Click to copy
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| 催产素与孤独症谱系障碍的发病关系及推拿干预效应的理论探索 |
| 智慧,冯祥,曾理,李武,李江山 |
| (湖南中医药大学针灸推拿与康复学院, 湖南 长沙 410208) |
| 摘要: |
| 孤独症谱系障碍（autism spectrum disorder，ASD），是以刻板重复行为、社交障碍、兴趣局限等为主要临床表现的神经发育障碍性疾病。推拿作为儿科常用的治疗手段之一，可显著改善ASD患儿的异常行为，改善其社会能力。在基础研究方面，催产素（oxytocin，OXT）含量下降是ASD发病的重要假说之一，而推拿的疗效可能与机械刺激激活C类触觉传入纤维从而上调OXT含量有关。从OXT角度讨论ASD发病的神经生物学机制，阐明OXT与ASD发病的潜在联系，即OXT异常导致ASD患者边缘奖赏系统功能受损进而诱发社交障碍，并论述推拿可能通过调节OXT含量产生治疗效应的具体机制。 |
| 关键词: 孤独症谱系障碍 催产素 推拿 社交行为 C类触觉传入纤维 神经生物学机制 |
| DOI：10.3969/j.issn.1674－070X.2024.04.014 |
| Received:December 24, 2023 |
| 基金项目:湖南省自然科学基金面上项目（2022JJ30434）；湖南省科技厅创新人才项目（2022RC1221）；湖南中医药大学研究生科研创新项目（2023CX76）。 |
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| Theoretical exploration on relationship between oxytocin and the pathogenesis of autism spectrum disorder as well as intervention effects of tuina |
| ZHI Hui,FENG Xiang,ZENG Li,LI Wu,LI Jiangshan |
| (School of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Autism spectrum disorder (ASD),is a neurodevelopmental disorder that is mainly clinical manifestations by repetitive behaviors,impaired social interaction,and limited interests.As one of the commonly used therapies in pediatrics,tuina can significantly reduce the abnormal behaviors and improve the social abilities in children with ASD.In terms of basic research,the decrease of oxytocin (OXT) content is one of the important hypotheses for the pathogenesis of ASD,and the therapeutic effects of tuina may be related to the upregulation of OXT content through the activation of C-tactile afferent fibers by mechanical stimulation.This paper discusses the neurobiological mechanism of ASD pathogenesis from the perspective of OXT,and elucidates the potential connection between OXT and ASD pathogenesis,that is,the abnormal OXT can lead to the impairment of limbic reward system function in ASD patients,further inducing impaired social interaction.In addition,it discusses the specific mechanism of how tuina may produce therapeutic effects by regulating OXT content. |
| Key words: autism spectrum disorder oxytocin tuina social behavior C-tactile afferent fibers neurobiological mechanism |
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