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杨丽萍,刘钰,周帅,李蒙,于希军.基于阴阳平衡理论重识巨噬细胞在创面愈合中的动态变化和分子机制[J].湖南中医药大学学报英文版,2024,44(3):510-515.[Click to copy
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| 基于阴阳平衡理论重识巨噬细胞在创面愈合中的动态变化和分子机制 |
| 杨丽萍,刘钰,周帅,李蒙,于希军 |
| (内蒙古医科大学, 内蒙古自治区 呼和浩特 010110;内蒙古医科大学, 内蒙古自治区 呼和浩特 010110;湖南中医药大学, 湖南 长沙 410208;内蒙古医科大学附属医院, 内蒙古自治区 呼和浩特 010110) |
| 摘要: |
| 阴阳平衡是中医理论的一个重要概念，中医学认为阴阳平衡才是机体的最佳状态。巨噬细胞调节创面再生修复，在不同刺激下可分化成M1型巨噬细胞和M2型巨噬细胞。M1型与M2型巨噬细胞在创面愈合过程中的动态变化与阴阳平衡理论内涵相似。如果在创面愈合过程中，巨噬细胞平衡被扰乱，阴阳失衡，则会导致过度炎症或者病理性瘢痕。以阴阳平衡理论为指导，从巨噬细胞表型出发就近年来对创面愈合的作用机制展开综述，以期为临床治疗提供新思路。 |
| 关键词: 创面愈合 M1型巨噬细胞 M2型巨噬细胞 表型 阴阳平衡 分子机制 |
| DOI：10.3969/j.issn.1674-070X.2024.03.026 |
| Received:August 31, 2023 |
| 基金项目:国家自然科学青年科学基金项目（82205127）；内蒙古自治区卫生健康委医疗卫生科技计划项目（202201189）；内蒙古自治区自然科学基金面上项目（2021MS08027，2022MS08021）；内蒙古医科大学面上项目（YKD2021MS023）。 |
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| Restudy of the dynamic changes and molecular mechanism of macrophages in wound healing based on yin-yang balance theory |
| YANG Liping,LIU Yu,ZHOU Shuai,LI Meng,YU Xijun |
| (Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China;Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China) |
| Abstract: |
| Yin-yang balance, an important concept in Chinese medicine, is considered to be the best state of the body in Chinese medicine. Macrophages regulate wound regeneration and repair, and can differentiate into M1 and M2 macrophages under different stimuli respectively. The dynamic changes of M1 and M2 macrophages during wound healing are similar to the connotation of yin-yang balance theory. If the balance of macrophages is disturbed during wound healing, yin and yang are out of balance, leading to excessive inflammation or pathological scarring. Guided by yin-yang balance theory, this paper reviews the mechanism of wound healing in recent years from the perspective of macrophage phenotype, in order to provide new ideas for clinical treatment. |
| Key words: wound healing M1 macrophage M2 macrophage phenotype yin-yang balance molecular mechanism |
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