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林可怡,余诗谣,丘宇慧,华荣.基于数据挖掘分析华荣解郁和中法论治偏头痛临床用药经验[J].湖南中医药大学学报英文版,2024,44(2):288-294.[Click to copy
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| 基于数据挖掘分析华荣解郁和中法论治偏头痛临床用药经验 |
| 林可怡,余诗谣,丘宇慧,华荣 |
| (广州中医药大学第二临床医学院, 广东 广州 510405;广州中医药大学第二附属医院, 广东 广州 510120) |
| 摘要: |
| 目的 基于真实世界数据，采用文本及数据挖掘的方法探讨华荣主任医师解郁和中法治疗偏头痛的临床经验及用药规律，以期为中医药治疗偏头痛提供诊疗方案及科学依据。方法 收集2019年1月1日至2021年12月31日广东省中医院华荣头痛门诊就诊并诊断为偏头痛患者的诊疗信息，利用Excel 2019和SPSS 18.0分别进行数据库构建、中药频次统计、四气五味归经分析及药物关联规则分析，并结合文本挖掘的方式，分析临床疗效。结果 共纳入符合标准的偏头痛患者200例，录入处方200首。共有中药99味，共计18味常用药物（频次>100次），主要有茯苓、甘草、白术、陈皮、半夏、延胡索、白芍、乌药等；四气以温、平为主；五味以辛、苦、甘为主；归经以脾、肺、胃、肝、心为主；药物关联规则共获得12条常用药物组合，最常用药物组合分别为茯苓-甘草、白术-甘草；15条关联规则，支持度较高的关联项分别为茯苓-甘草、白术-茯苓、白术-甘草。临床疗效总有效率为98.5%。结论 华荣论治偏头痛注重整体动态同调，以调畅肝脾胃气机为核心，以健脾解郁和中为治法，兼以辛开苦降、苦温燥湿、温化痰饮、培土生金等治法。 |
| 关键词: 偏头痛 临床用药经验 肝脾胃同调 解郁和中法 真实世界 数据挖掘 华荣 |
| DOI：10.3969/j.issn.1674-070X.2024.02.016 |
| Received:November 03, 2023 |
| 基金项目:国家科技重点研发计划课题项目（2019YFC1708601）；广东省中医院中医学术流派传承工作室建设项目岭南林夏泉学术流派传承工作室资助项目（E43604）。 |
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| HUA Rong’s clinical medication experience in treating migraine with the method of relieving depression and harmonizing the middle jiao based on data mining |
| LIN Keyi,YU Shiyao,QIU Yuhui,HUA Rong |
| (The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China;The Second Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, China) |
| Abstract: |
| Objective To explore the chief physician HUA Rong's clinical experience and medication rules in treating migraine with the method of relieving depression and harmonizing the middle jiao, by text and data mining methods based on the real-world data, and to further provide diagnosis and treatment plans and scientific basis for TCM treatment of migraine.Methods The diagnosis and treatment information of patients diagnosed with migraine in HUA Rong's headache outpatient department of Guangdong Hospital of Chinese Medicine from January 1st, 2019 to December 31st, 2021 was collected. Microsoft Office Excel2019 and SPSS Modeler 18.0 were used for database construction, medication frequency statistics, as well as analyses of properties,flavors, and meridian affinity of the involved Chinese medicines and the association rule, and text mining was also combined to analyze the clinical efficacy.Results A total of 200 patients with migraine meeting the criteria were included and 200 formulas were collected. There were 99 Chinese medicines in total, among which 18 medicines were commonly used(frequency>100 times),mainly including Fuling(Poria), Gancao(Glycyrrhizae Radix et Rhizoma), Baizhu(Atractylodis Macrocephalae Rhizoma), Chenpi(Citri Reticulatae Pericarpium), Banxia(Pinelliae Rhizoma), Yanhusuo(Corydalis Rhizoma), Baishao(Paeoniae Radix Alba), Wuyao(Linderae Radix), etc; the involved Chinese medicines were mainly warm and neutral in property, and pungent, bitter, and sweet in flavor, entering the spleen, lung, stomach, liver, and heart meridians. Twelve combinations of medicines were obtained through the association rule analysis, among which the most commonly used ones were Fuling(Poria)-Gancao(Glycyrrhizae Radix et Rhizoma)and Baizhu(Atractylodis Macrocephalae Rhizoma)-Gancao(Glycyrrhizae Radix et Rhizoma); fifteen association rules were yielded,among which the association items with higher support were Fuling(Poria)-Gancao(Glycyrrhizae Radix et Rhizoma), Baizhu(Atractylodis Macrocephalae Rhizoma)-Fuling(Poria), and Baizhu(Atractylodis Macrocephalae Rhizoma)-Gancao(Glycyrrhizae Radix et Rhizoma). The total effective rate of the clinical treatment was 98.5%.Conclusion HUA Rong's treatment of migraine mainly emphasizes holistic dynamic coordination, with regulating the qi movement of the liver, spleen, and stomach as the core and relieving depression and harmonizing the middle jiao as the main method, and also assisted by methods such as opening with pungent medicines and descending with bitter medicines, drying dampness with medicines warm in property and bitter in flavor,warming and transforming phlegm and fluid retention, and cultivating earth to generate metal. |
| Key words: migraine clinical medication experience regulating the liver,spleen,and stomach simultaneously method of relieving depression and harmonizing the middle jiao real-world data data mining HUA Rong |
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