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王欣,景慧玲,李静怡,姚婕,王星星.止痛消炎膏治疗聚合性痤疮的临床观察及对皮肤屏障功能的影响[J].湖南中医药大学学报英文版,2023,43(10):1864-1867.[Click to copy
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| 止痛消炎膏治疗聚合性痤疮的临床观察及对皮肤屏障功能的影响 |
| 王欣,景慧玲,李静怡,姚婕,王星星 |
| (陕西中医药大学, 陕西 咸阳 712046;西安市中医医院, 陕西 西安 710021) |
| 摘要: |
| 目的 评价止痛消炎膏治疗聚合性痤疮的临床疗效及其对皮肤屏障功能的影响。方法 收集2022年4月至2022年10月就诊于西安市中医医院皮肤科门诊的聚合性痤疮患者共100例，采用随机数字表法均分为两组，对照组给予适量夫西地酸乳膏外用；试验组给予适量止痛消炎膏外用，两组患者均治疗4周。比较两组患者治疗前后经表皮水分流失（transepidermal water loss, TEWL）、角质层含水量（stratum corneum hydration, SCH）、皮肤湿度、痤疮综合分级系统（global acne grading system, GAGS）评分、临床疗效，并记录不良反应及复发率。结果 治疗4周后，试验组GAGS评分、TEWL、复发率均低于对照组，临床疗效指数、SCH、皮肤湿度均高于对照组（P＜0.05），且只有1例出现轻微不良反应。结论 止痛消炎膏治疗聚合性痤疮疗效显著，且能改善痤疮患者皮肤屏障功能。 |
| 关键词: 聚合性痤疮 止痛消炎膏 夫西地酸 皮肤屏障功能 经表皮水分流失 痤疮综合分级系统评分 |
| DOI：10.3969/j.issn.1674-070X.2023.10.017 |
| Received:April 13, 2023 |
| 基金项目:西安市卫生健康委员会中医药科研项目（SZL202206）；陕西省自然科学基础研究计划项目（2023-JC-QN-0952）；西安市卫生健康委员会科研项目（2023qn20）。 |
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| Clinical observation of Zhitong Xiaoyan Ointment in treating acne conglobata and its effects on skin barrier function |
| WANG Xin,JING Huiling,LI Jingyi,YAO Jie,WANG Xingxing |
| (Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China;Xi'an Hospital of Chinese Medicine, Xi'an, Shaanxi 710021, China) |
| Abstract: |
| Objective To evaluate the clinical efficacy of Zhitong Xiaoyan Ointment (ZTXYO) in treating acne conglobata and its effects on skin barrier function. Methods A total of 100 patients with acne conglobata in the Department of Dermatology of Xi'an Hospital of Chinese Medicine from April 2022 to October 2022 were collected and randomly divided into two groups by random number table method. Control group and experimental group were respectively given appropriate amount of fusidic acid cream and ZTXYO for external use. Both groups were treated for 4 weeks. Transepidermal water loss (TEWL), stratum corneum hydration (SCH), skin humidity, global acne grading system (GAGS) score, and clinical efficacy were compared between the two groups before and after treatment. Adverse reactions and recurrence rate were recorded. Results After 4 weeks of treatment, experimental group showed lower GAGS score, TEWL, and recurrence rate and higher clinical efficacy index, SCH, and skin humidity than those of control group (P＜0.05). Only one case had a mild adverse reaction. Conclusion ZTXYO has significant effects on acne conglobata, and can improve the skin barrier function of acne patients. |
| Key words: acne conglobata Zhitong Xiaoyan Ointment fusidic acid skin barrier function transepidermal water loss global acne grading system score |
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