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赵承启,邹伟.中医药调控细胞焦亡干预缺血性脑卒中的研究进展[J].湖南中医药大学学报英文版,2023,43(9):1742-1748.[Click to copy
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| This paper
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| 中医药调控细胞焦亡干预缺血性脑卒中的研究进展 |
| 赵承启,邹伟 |
| (黑龙江中医药大学, 黑龙江 哈尔滨 150040;黑龙江中医药大学附属第一医院, 黑龙江 哈尔滨 150040) |
| 摘要: |
| 细胞焦亡是一种促炎性程序性细胞死亡，通常经病原体感染后触发，是固有免疫的重要组成部分。细胞焦亡在缺血性脑卒中的发生发展中发挥着重要的作用。从细胞焦亡的作用机制、细胞焦亡与缺血性脑卒中的作用关系、中医药调控细胞焦亡干预缺血性脑卒中的研究进展等方面进行梳理与总结，发现细胞焦亡的关键介导因子是防治缺血性脑卒中的重要作用靶点。中药提取物、中药复方、针刺、电针疗法均能够通过抑制核苷酸结合寡聚化结构域样受体蛋白3、胱天蛋白酶-1、焦孔素-D或凋亡相关微粒蛋白等蛋白的表达，调控细胞焦亡而发挥治疗作用，为中医药防治缺血性脑卒中提供了新的思路和方向。 |
| 关键词: 缺血性脑卒中 细胞焦亡 针刺 免疫 核苷酸结合寡聚化结构域样受体蛋白3 胱天蛋白酶-1 焦孔素-D 凋亡相关微粒蛋白 |
| DOI：10.3969/j.issn.1674-070X.2023.09.030 |
| Received:March 25, 2023 |
| 基金项目:黑龙江省中医药管理局省级名中医专家传承工作室（20190529）。 |
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| Research progress on Chinese medicine in regulating pyroptosis for ischemic stroke |
| ZHAO Chengqi,ZOU Wei |
| (Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;The First Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China) |
| Abstract: |
| As a pro-inflammatory programmed cell death, pyroptosis is usually triggered by pathogen infection. It is not only an important component of innate immunity, but also plays an important role in the occurrence and development of ischemic stroke. This paper has sorted out and summarized the mechanism of action of pyroptosis, the relationship between pyroptosis and ischemic stroke, and the research progress of Chinese medicine in regulating pyroptosis to intervene ischemic stroke. It has been found that the key mediators of pyroptosis are important action targets for the prevention and treatment of ischemic stroke. In addition, several treatment methods of Chinese medicine, such as Chinese medicine extracts, Chinese herbal compound, acupuncture, and electro-acupuncture, have therapeutic effects on regulating pyroptosis by inhibiting protein expressions of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), caspase-1, gasdermin D, or apoptosis-associated speck-like protein, which provides a new idea and direction for the prevention and treatment of ischemic stroke by Chinese medicine. |
| Key words: ischemic stroke pyroptosis acupuncture immunity nucleotide-binding oligomerization domain-like receptor protein 3 caspase-1 gasdermin D apoptosis-associated speck-like protein |
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