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丛迪迪,梁群,付晨菲,赵佳瑶,王龙.中医药多靶点干预脓毒症急性肺损伤机制研究概述[J].湖南中医药大学学报英文版,2023,43(7):1336-1342.[Click to copy
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| 中医药多靶点干预脓毒症急性肺损伤机制研究概述 |
| 丛迪迪,梁群,付晨菲,赵佳瑶,王龙 |
| (黑龙江中医药大学, 黑龙江 哈尔滨 150040;黑龙江中医药大学, 黑龙江 哈尔滨 150040;黑龙江中医药大学附属第一医院, 黑龙江 哈尔滨 150040) |
| 摘要: |
| 脓毒症急性肺损伤是重症医学科的常见疾病，其病死率高，住院费用高，是危重症疾病领域研究的重点。目前针对脓毒症急性肺损伤的治疗尚无推荐的药理干预措施，中医药基于整体观及辨证论治理念治疗脓毒症急性肺损伤，彰显出多层次、多靶点、多途径的治疗特点，可通过干预炎性因子及炎症信号通路、抗氧化应激、抑制细胞凋亡等途径全面防治脓毒症急性肺损伤。通过回顾总结中医药治疗脓毒症急性肺损伤的实验研究，以期明确其机制和特点，为下一步研发治疗用药提供思路与方向。 |
| 关键词: 脓毒症 急性肺损伤 发病机制 中医药 综述 |
| DOI：10.3969/j.issn.1674-070X.2023.07.030 |
| Received:February 24, 2023 |
| 基金项目:国家自然科学基金面上项目（81974557，81774276）；黑龙江中医药大学校级科技创新研究平台项目（2018pt06）。 |
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| Review on multi-target intervention mechanism of Chinese medicine on sepsis-induced acute lung injury |
| CONG Didi,LIANG Qun,FU Chenfei,ZHAO Jiayao,WANG Long |
| (Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;The First Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China) |
| Abstract: |
| Sepsis-induced acute lung injury (ALI) is a common disease in the intensive care medicine with high mortality and needs high hospitalization cost. It is the research focus of critical illness. However, there has been no recommended pharmacological intervention for its treatment in western medicine. Chinese medicine treats it based on the holistic concept and pattern identification, and the treatment features as multi-level, multi-target, and multi-channel. To be specific, Chinese medicine can comprehensively prevent and treat sepsis-induced ALI by regulating inflammatory factors and inflammatory signaling pathways, taking effects of antioxidative stress, inhibiting cell apoptosis, and other ways. By reviewing and summarizing experimental research on the treatment of sepsis-induced ALI with Chinese medicine, we hope to clarify its mechanism and characteristics, and provide ideas and directions for the further research and development of therapeutic drugs of this disease. |
| Key words: sepsis acute lung injury pathogenesis Chinese medicine review |
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