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郭圣挥,陈勇喜,秦刚,刘科第,蒙觉威,覃忠设,李品元.补肝强肾壮骨方联合针灸治疗老年性骨质疏松症的临床观察[J].湖南中医药大学学报英文版,2023,43(5):897-901.[Click to copy
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| 补肝强肾壮骨方联合针灸治疗老年性骨质疏松症的临床观察 |
| 郭圣挥,陈勇喜,秦刚,刘科第,蒙觉威,覃忠设,李品元 |
| (广西中医药大学研究生院, 广西 南宁 530003;广西中医药大学第一附属医院骨一科, 广西 南宁 530003;横州市中医医院, 广西 横州 530004) |
| 摘要: |
| 目的 观察补肝强肾壮骨方联合针灸治疗老年性骨质疏松症的临床疗效。方法 选取广西中医药大学第一附属医院脊柱外科门诊2020年2月至2022年2月收治的50例老年性骨质疏松症患者,采取随机数字表法分成对照组和观察组,各25例。对照组给予常规西药治疗,观察组在对照组基础上口服补肝强肾壮骨方联合针灸治疗,共治疗6个月。对比治疗前后两组患者的骨密度(bone mineral density, BMD)、视觉模拟评分(visual analogue scale, VAS)、血钙浓度、骨代谢指标[骨特异性碱性磷酸酶(bone specific alkaline phosphatase, BAP)、骨钙素(osteocalcin, BGP)、甲状旁腺激素(parathyroid hormone, PTH)],以及治疗不良反应发生率。结果 治疗前,两组患者的BMD、VAS评分、血钙浓度以及骨代谢指标(BAP、BGP、PTH)比较,差异无统计学意义(P>0.05)。治疗6个月后,两组BMD、血钙浓度、BAP、BGP水平较治疗前明显增高(P<0.05),VAS评分、PTH较治疗前下降(P<0.05);观察组BMD、血钙浓度、BAP、BGP水平显著高于对照组(P<0.05),VAS评分、PTH显著低于对照组(P<0.05)。观察组治疗后不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论 补肝强肾壮骨方联合针灸治疗老年性骨质疏松症具有很好的临床疗效,可有效减轻患者腰背痛、提高BMD、调节骨代谢指标,从而改善患者的生活质量。 |
| 关键词: 老年性骨质疏松症 补肝强肾壮骨方 针灸 腰背痛 骨密度 骨代谢 临床观察 |
| DOI：10.3969/j.issn.1674-070X.2023.05.020 |
| Received:October 18, 2022 |
| 基金项目:国家自然科学基金项目（81860793）；广西壮族自治区中医药管理局适宜技术开发与推广项目（GZSY23-28）。 |
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| Clinical observation of Bugan Qiangshen Zhuanggu Formula combined with acupuncture in treating senile osteoporosis |
| GUO Shenghui,CHEN Yongxi,QIN Gang,LIU Kedi,MENG Juewei,QIN Zhongshe,LI Pinyuan |
| (Graduate School of Guangxi University of Chinese Medicine, Nanning, Guangxi 530003, China;Department of Orthopedics, The First Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi 530003, China;Hengzhou Chinese Medicine Hospital, Hengzhou, Guangxi 530004, China) |
| Abstract: |
| Objective To observe the clinical effects of Bugan Qiangshen Zhuanggu Formula (BGQSZGF) combined with acupuncture on senile osteoporosis. Methods A total of 50 elderly patients with osteoporosis admitted to the Spinal Surgery Outpatient of the First Hospital of Guangxi University of Chinese Medicine from February 2020 to February 2022 were selected and randomly divided into control group (n=25) and observation group (n=25). The control group was treated with conventional western medicine, while the observation group was treated with BGQSZGF combined with acupuncture for 6 months. The bone mineral density (BMD), visual analogue scale (VAS), blood calcium concentration, bone metabolism indicators [bone specific alkaline phosphatase (BAP), osteocalcin (BGP), parathyroid hormone (PTH)], and incidence of adverse reactions before and after treatment between the two groups were compared. Results Before the treatment, there was no statistically significant difference in BMD, VAS score, blood calcium concentration, and bone metabolism indicators (BAP, BGP, PTH) between the two groups (P>0.05). After 6 months of treatment, compared with those before treatment, BMD, blood calcium concentration, BAP, and BGP levels in both groups were significantly higher (P<0.05), while VAS score and PTH were lower (P<0.05); compared with those in the control group, the levels of BMD, blood calcium concentration, BAP, and BGP in the observation group were significantly higher (P<0.05), while the VAS score and PTH were significantly lower (P<0.05). The incidence of adverse reactions after treatment in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion BGQSZGF combined with acupuncture has good clinical effects on senile osteoporosis, which can effectively relieve patients' low back pain, increase BMD, and regulate bone metabolism indicators, thus improving patients' quality of life. |
| Key words: senile osteoporosis Bugan Qiangshen Zhuanggu Formula acupuncture low back pain bone density bone metabolism clinical observation |
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