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周家谭,卢健棋,罗文宽,杨敏.中医药干预NF-κB信号通路防治高血压靶器官损伤的实验研究进展[J].湖南中医药大学学报英文版,2023,43(4):747-752.[Click to copy
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| 中医药干预NF-κB信号通路防治高血压靶器官损伤的实验研究进展 |
| 周家谭,卢健棋,罗文宽,杨敏 |
| (广西中医药大学, 广西 南宁 530000;广西中医药大学第一附属医院心内科/国家中医心血管病临床医学研究中心分中心, 广西 南宁 530000) |
| 摘要: |
| 高血压是多种心血管疾病的重要危险因素之一，长期持续血压升高可导致心、脑、肾、血管等靶器官的损伤，且其患病率及致残率呈不断攀升趋势。高血压靶器官损伤过程与免疫炎症失调相关，而核因子κB（nuclear factor-κB, NF-κB）是介导炎症反应的枢纽。NF-κB信号通路是中医药防治高血压靶器官损伤的重要靶点之一。对近5年来国内外中药单体及其有效成分、复方制剂、针灸作用于NF-κB信号通路而防治高血压所致心、脑、肾及血管等靶器官损伤的实验研究进行综述，旨在为中医药防治高血压靶器官损伤提供新的理论依据与思路。 |
| 关键词: 高血压 NF-κB信号通路 中医药 靶器官 靶器官损伤 |
| DOI：10.3969/j.issn.1674-070X.2023.04.028 |
| Received:November 18, 2022 |
| 基金项目:国家自然科学基金项目（82160887）；国家中医药管理局国家中医临床研究基地业务建设科研专项课题（JDZX2015146）；广西自然科学基金项目（2021GXNSFBA196018，2021GXNSFAA220111）；2022年中央补助广西医疗服务与保障能力提升（中医药传承与发展部分）-中医药领军人才项目-岐黄学者培养（2022015-003-02）。 |
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| Experimental research progress of Chinese medicine intervention in NF-κB signaling pathway to prevent and treat target organ damage in hypertension |
| ZHOU Jiatan,LU Jianqi,LUO Wenkuan,YANG Min |
| (Guangxi University of Chinese Medicine, Nanning, Guangxi 530000, China;Department of Cardiolog/The First Hospital of Guangxi University of Chinese Medicine/Sub-center of National Center for Clinical Research of TCM Cardiovascular Diseases, Nanning, Guangxi 530000, China) |
| Abstract: |
| Hypertension is one of the important risk factors for many cardiovascular diseases. The prolonged high blood pressure can cause damage to target organs such as the heart, brain, kidneys and blood vessels, and its prevalence and disability rate are increasing. The damage of target organ for hypertension patients is related to the imbalanced immune inflammation, and nuclear factor-κB (NF-κB) is the hub of mediating inflammatory response. NF-κB signaling pathway is one of the important target sites of Chinese medicine in preventing and treating target organ damage of hypertension cases. This paper has reviewed the researches in the past five years on the prevention and treatment of target organ (heart, brain, kidneys, blood vessels etc.) damage due to hypertension by the way that Chinese medicine monomer and its effective components, compound preparations and acupuncture acts on NF-κB signaling pathway. It aims to provide new theoretical bases and ideas for preventing and treating target organ damage of hypertension with Chinese medicine. |
| Key words: hypertension NF-κB signaling pathway Chinese medicine target organ target organ damage |
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