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王聪慧,娄锡恩,卞兆祥.基于肠道菌群失调探析中医从脾论治高尿酸血症的科学内涵[J].湖南中医药大学学报英文版,2023,43(4):729-734.[Click to copy
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| 基于肠道菌群失调探析中医从脾论治高尿酸血症的科学内涵 |
| 王聪慧,娄锡恩,卞兆祥 |
| (北京中医药大学第三临床医学院, 北京 100029;北京中医药大学第三附属医院内分泌科, 北京 100029;香港浸会大学深圳研究院, 广东 深圳 518000) |
| 摘要: |
| 肠道菌群是人体代谢的重要参与者。肠道菌群失调与高尿酸血症（hyperuricemia, HUA）互为因果，肠道菌群结构的紊乱、肠道物质环境的改变以及肠道代谢物的变化皆可导致HUA的发生。中医“脾”之功能健运是肠道稳态的重要条件，而脾失运化则是HUA病机的核心。通过论述肠道菌群、脾与HUA三者之间的关联，探讨HUA的病机特点及科学内涵。 |
| 关键词: 肠道菌群 高尿酸血症 脾主运化 病机 科学内涵 |
| DOI：10.3969/j.issn.1674-070X.2023.04.025 |
| Received:January 06, 2023 |
| 基金项目:国家重点研发计划项目（2019YFC1710403）。 |
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| Scientific connotation of treaing hyperuricemia from a TCM perspective of “spleen-based therapy” based on analysis of intestinal microbiota imbalance |
| WANG Conghui,LOU Xi'en,BIAN Zhaoxiang |
| (The Third Clinical School of Beijing University of Chinese Medicine, Beijing 100029, China;Department of Endocrinology, The Third Hospital of Beijing University of Chinese Medicine, Beijing 100029, China;Shenzhen Research Institute of Hong Kong Baptist University, Shenzhen, Guangdong 518000, China) |
| Abstract: |
| The intestinal microbiota plays a significant role in human metabolism. The imbalance of intestinal microbiota are causally related to hyperuricemia (HUA), with disruptions in the structure of the intestinal microbiota, changes in the intestinal environment, and changes in intestinal metabolites all contributing to hyperuricemia. The healthy function of the spleen in Chinese medicine is crucial for intestinal homeostasis. However, dysfunction of the spleen in transportation and transformation is the core pathogenesis of HUA. This paper explores the pathogenesis characteristics and scientific connotations of HUA by discussing the relationship between intestinal microbiota, spleen and HUA. |
| Key words: intestinal microbiota hyperuricemia the spleen governing transportation and transformation pathogenesis scientific connotation |
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