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毛果,谢乐,周胜强,谢瑶,毛叶,马健航,伍大华,刘柏炎.桑丹通络颗粒治疗阴虚血瘀证缺血性脑卒中恢复期的回顾性队列研究[J].湖南中医药大学学报英文版,2023,43(4):633-637.[Click to copy
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| 桑丹通络颗粒治疗阴虚血瘀证缺血性脑卒中恢复期的回顾性队列研究 |
| 毛果,谢乐,周胜强,谢瑶,毛叶,马健航,伍大华,刘柏炎 |
| (湖南中医药大学, 湖南 长沙 410208;湖南省中西医结合医院（湖南省中医药研究院附属医院）, 湖南 长沙 410006;湖南中医药大学, 湖南 长沙 410208;湖南省中医药研究院, 湖南 长沙 410006) |
| 摘要: |
| 目的 评价桑丹通络颗粒治疗阴虚血瘀证缺血性脑卒中恢复期的临床有效性与安全性。方法 采用回顾性队列研究方法，通过湖南省中医药研究院附属医院门诊与住院病历系统收集2021年7月至2022年6月收治的缺血性脑卒中恢复期患者临床资料，选择应用桑丹通络颗粒联合西医常规治疗的51例患者为暴露组，匹配仅应用西医常规治疗的102例患者为对照组，两组均治疗2周。比较治疗前后总有效率、美国国立卫生研究院卒中量表（National Institute of Health Stroke Scale, NIHSS）评分、日常生活活动能力（activity of daily living, ADL）评分、血脂水平、血液流变学指标和症状总积分等，并对所有患者治疗期间不良反应事件进行记录。结果 暴露组临床总有效率84.31%，高于对照组的67.65%（P＜0.05）。与治疗前比较，两组治疗后NIHSS、TC、LDL降低（P＜0.01或P＜0.05），且暴露组低于对照组（P＜0.05）；两组ADL升高（P＜0.01），且暴露组高于对照组（P＜0.01）。与治疗前比较，暴露组治疗后症状总积分、血液流变学各项指标降低（P＜0.01或P＜0.05），且暴露组低于对照组（P＜0.01或P＜0.05）；HDL-C升高（P＜0.01），且暴露组高于对照组（P＜0.01）。结论 桑丹通络颗粒联合西医常规治疗可明显改善阴虚血瘀证缺血性脑卒中恢复期患者症状，降低其神经缺损程度，改善血脂水平和血液流变学指标，有效提高其生存质量，疗效确切且安全稳定。因此，推测桑丹通络颗粒具有一定的临床应用与推广价值。 |
| 关键词: 缺血性脑卒中 阴虚血瘀证 桑丹通络颗粒 回顾性队列研究 美国国立卫生研究院卒中量表 日常生活活动能力 |
| DOI：10.3969/j.issn.1674-070X.2023.04.009 |
| Received:October 10, 2022 |
| 基金项目:湖南省自然科学青年基金项目（2021JJ40313）；湖南省科技厅临床医疗技术创新引导项目（2020SK51003）；湖南省中医药管理局一般项目（2021084）。 |
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| A retrospective cohort study of Sangdan Tongluo Granule treating convalescence of ischemic stroke with yin deficiency and blood stasis pattern |
| MAO Guo,XIE Le,ZHOU Shengqiang,XIE Yao,MAO Ye,MA Jianhang,WU Dahua,LIU Baiyan |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Hospital of Integrated Chinese and Western Medicine (The Hospital of Hunan Academy of Chinese Medicine), Changsha, Hunan 410006, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Academy of Chinese Medicine, Changsha, Hunan 410006, China) |
| Abstract: |
| Objective To evaluate the clinical efficacy and safety of Sangdan Tongluo Granule treating convalescence of ischemic stroke with yin deficiency and blood stasis pattern.Methods A retrospective cohort study was performed, in which the clinical data of patients in the convalescence of ischemic stroke from July 2021 to June 2022 was collected through the system of outpatient and inpatient medical records in the Hospital of Hunan Academy of Chinese Medicine. A total of 51 patients treated with Sangdan Tongluo Granule combined with conventional therapy of western medicine were selected as exposure group, and 102 patients treated with conventional therapy of western medicine only were selected as control group. Both groups were treated for 2 weeks. The total clinical effective rate, National Institutes of Health Stroke Scale (NIHSS) score, activity of daily living (ADL) score, serum lipid levels, hemorheological indexes and total symptom score etc. were compared before and after treatment, and the adverse reactions of all patients during treatment were recorded.Results The total clinical effective rate of exposure group was 84.31%, which was higher than 67.65% of control group (P<0.05). NIHSS score and the levels of TC and LDL in both groups decreased (P<0.01 or P<0.05) after treatment, and the results in exposure group were lower than those in control group (P<0.05). ADL score elevated in both groups (P<0.01), and the score in exposure group was higher than that in control group (P<0.01). The total symptom score and hemorheological indexes of exposed group after treatment were reduced (P<0.01 or P<0.05), and the results in exposed group were lower than those in control group (P<0.01 or P<0.05). The level of HDL-C went up (P<0.01) and the content in exposure group was higher than that in control group (P<0.01).Conclusion The curative effect of Sangdan Tongluo Granule combined with conventional therapy of western medicine is accurate, safe and stable, which can significantly improve the symptoms of patients in the convalescence of ischemic stroke with yin deficiency and blood stasis pattern. It can also reduce the degree of nerve defect, improve serum lipid levels and hemorheological indexes as well as the patients' quality of life. To sum up, we hold that Sangdan Tongluo Granule has certain value for clinical application and promotion. |
| Key words: ischemic stroke yin deficiency and blood stasis pattern Sangdan Tongluo Granule retrospective cohort study National Institute of Health Stroke Scale activity of daily living score |
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