| Quote
: |
王子焱,欧阳青兰,谭超.基于数据挖掘的国医大师熊继柏治疗胸痹心痛方药规律研究[J].湖南中医药大学学报英文版,2023,43(2):189-196.[Click to copy
] |
|
| |
|
|
| This paper
：Browser 1211times Download 600times |
| 基于数据挖掘的国医大师熊继柏治疗胸痹心痛方药规律研究 |
| 王子焱,欧阳青兰,谭超 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学研究生院, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007;国医大师熊继柏传承工作室, 湖南 长沙 410007) |
| 摘要: |
| 目的 挖掘熊继柏教授治疗胸痹心痛的用药规律、用方经验及学术特色，为胸痹心痛的临床治疗与新药开发提供参考与借鉴。方法 采集2017年1月1日至2020年12月31日熊继柏教授于湖南中医药大学第一附属医院诊疗胸痹心痛患者的处方419首，录入中医传承计算平台V3.0，运用软件统计证候，治则治法，方剂以及药物、四气、五味、归经、功效频次，并进行药物聚类分析。结果 所用药物多为甘、苦药，归经以肺经为主，其次为心、脾、胃、肝、肾经；使用最多的方剂是十味温胆汤，其次为小陷胸汤、颠倒木金散、葛根姜黄散等方剂；高频药物主要有法半夏、丹参、酸枣仁、陈皮、西洋参、枳实、竹茹、远志等；组方规律分析得到常用药组合129个，置信度>0.99的组合有17个，其中置信度为1的组合有8个；药物聚类得到5个核心药物组合，方1功能益气养阴，豁痰化瘀；方2功能理气化痰，和胃利胆；方3功能豁痰化瘀，养心安神；方4功能清热化痰，行气解郁；方5功能清热化痰，宁心安神。结论 熊继柏教授认为胸痹心痛的核心病机为心气不足，痰瘀互结，处方以十味温胆汤为基础方加减化裁、其用药特色为寒温并用，虚实同调；审察病机，因证选方；分辨主次，随症加减。 |
| 关键词: 胸痹 心痛 冠心病 心绞痛 数据挖掘 用药规律 十味温胆汤 颠倒木金散 熊继柏 |
| DOI：10.3969/j.issn.1674-070X.2023.02.003 |
| Received:August 22, 2022 |
| 基金项目:湖南省中医药科研计划项目（2021134）；湖南中医药大学国内一流建设学科开放基金项目（2018ZYX41）。 |
|
| Medication rules of TCM Master XIONG Jibo in treating chest bi-impediment and heartache by data mining |
| WANG Ziyan,OUYANG Qinglan,TAN Chao |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Graduate School of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Inherit Workroom of TCM Master XIONG Jibo's Experiences, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To investigate Professor XIONG Jibo's medication rules, prescription experience and academic characteristics in the treatment of chest bi-impediment and heartache by data mining, so as to provide reference for clinical treatment and new drug development. Methods A total of 419 formulas for chest bi-impediment and heartache patients diagnosed and treated by Professor XIONG Jibo in the First Hospital of Hunan University of Chinese Medicine from January 1, 2017 to December 31, 2020 were collected and entered into Chinese Medicine Inheritance Computing Platform (V3.0). Then, we obtained the syndromes, treatment principles and methods, formulas, and the four qi, five flavors, meridian tropisms, and efficacy of medicines. We also performed the drug cluster analysis. Results Most of the medicines were sweet and bitter and they mainly accessed to the lung channel, followed by the heart, spleen, stomach, liver and kidney channels. The most commonly used formulas were Shiwei Wendan Decoction, followed by Xiaoxianxiong Decoction, Diandao Mujin Powder, Gegen Jianghua Powder, and others. The high-frequency medicines were mainly Fabanxia (Rhizoma Pinelliae Preparatum), Danshen (Radix Salviae Miltiorrhizae), Suanzaoren (Semen Ziziphi Spinosae), Chenpi (Pericarpium Citri Reticulatae), Xiyangshen (Radix Panacis Quinquefolii), Zhishi (Fructus Aurantii Immaturus), Zhuru (Caulis Bambusae in Taenia), Yuanzhi (Radix Polygalae) and others. By analyzing the composition rule, 129 commonly used combinations were obtained, among which 17 with the confidence higher than 0.99, and 8 with the confidence of 1. Five core drug combinations were obtained by drug clustering, including Formula 1 (nourishing qi and yin, eliminating phlegm and resolving stasis), Formula 2 (regulating qi and resolving phlegm, and harmonizing stomach and gallbladder), Formula 3 (eliminating phlegm and resolving stasis, nourishing the heart and calming the nerves), Formula 4 (clearing heat and resolving phlegm, promoting qi and resolving depression), and Formula 5 (clearing heat and resolving phlegm, calming the heart and calming the nerves). Conclusion According to Professor XIONG Jibo, the core pathogenesis of chest bi-impediment and heartache is lack of heart qi, phlegm and blood stasis, and the formula should be the modified Shiwei Wendan Decoction. Both cold and warm medicines should be combined and deficiency and excess should be regulated simutaneously. Moreover, he identified the formula based on patterns after examining the pathogenesis, and it should be modified following symptoms based on identifying the primary and secondary. |
| Key words: chest bi-impediment heartache coronary heart disease angina pectoris data mining medication rules Shiwei Wendan Decoction Diandao Mujin Powder XIONG Jibo |
|
二维码（扫一下试试看！） |
|
|
|
|
