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谭骏岚,殷淑婷,易健,李霞,覃丽,戴爱国.GSDME介导的细胞焦亡在非肿瘤疾病中的研究进展[J].湖南中医药大学学报英文版,2022,42(12):2122-2127.[Click to copy
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| GSDME介导的细胞焦亡在非肿瘤疾病中的研究进展 |
| 谭骏岚,殷淑婷,易健,李霞,覃丽,戴爱国 |
| (湖南中医药大学, 湖南 长沙 410208;血管生物学与转化医学湖南省高校重点实验室, 湖南 长沙 410208;湖南中医药大学, 湖南 长沙 410208;血管生物学与转化医学湖南省高校重点实验室, 湖南 长沙 410208;湖南中医药大学第一附属医院呼吸科, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208;血管生物学与转化医学湖南省高校重点实验室, 湖南 长沙 410208;湖南中医药大学药学院, 湖南 长沙 410208) |
| 摘要: |
| Gasdermin E(GSDME)是Gasdermin(GSDM)基因家族成员之一,可能与肿瘤及其他多种疾病的发生发展相关。最新研究发现,GSDME在感染、自身免疫性疾病、心血管疾病等非肿瘤疾病的病变组织中高表达,可被激活的天冬氨酸特异性半胱氨酸蛋白酶3(cysteine-containing aspartate specific proteinase 3, Caspase-3)特异性切割,形成具有造孔活性的GSDME-N片段介导细胞焦亡,从而促进疾病的发生发展。此外,通过药物靶向调控Caspase-3/GSDME介导的细胞焦亡途径已在多种疾病模型中展现出较大的治疗潜力,未来有望临床转化。本文综述GSDME介导的细胞焦亡在非肿瘤疾病中的作用,以及相关药物干预的研究进展。 |
| 关键词: 细胞焦亡 GSDME GSDMD Caspase-3 感染 自身免疫性疾病 |
| DOI：10.3969/j.issn.1674-070X.2022.12.028 |
| Received:May 16, 2022 |
| 基金项目:国家自然科学基金项目(81973668,81570052); 湖南省自然科学基金项目(2021JJ30017); 中国博士后科学基金面上项目(2021M690982); 湖南省中医药科研计划重点项目(C2022001); 湖南省中药粉体与创新药物研究省部共建国家重点实验室培育基地开放基金项目(21PTKF1001); 湖南省研究生科研创新项目(CX20220823) |
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| Research progress of GSDME-mediated pyroptosis in non-tumor diseases |
| TAN Junlan,YIN Shuting,YI Jian,LI Xia,TAN Li,DAI Aiguo |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha, Hunan 410208, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha, Hunan 410208, China;Department of Respiratory Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha, Hunan 410208, China;School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Gasdermin E(GSDME) is a member of the Gasdermin(GSDM) gene family that may be associated with the development of cancer and a variety of other diseases. Recent studies have revealed that GSDME is highly expressed in diseased tissues of non-tumor diseases such as infections, autoimmune diseases, and cardiovascular diseases, and can be specifically cleaved by activated cysteine-containing aspartate specific proteinase 3(Caspase-3) to form a GSDME-N fragment with pore-forming activity that mediates pyroptosis and thus contributes to disease progression. Moreover, the regulation of Caspase-3/GSDME-mediated pyroptosis pathway by drug targeting has shown a large therapeutic potential in multiple disease models, which is expected to be clinically translated in the future. This article reviews the role of GSDME-mediated pyroptosis in non-tumor diseases and the progress of related drug intervention studies. |
| Key words: pyroptosis GSDME GSDMD Caspase-3 infection autoimmune disease |
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