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黄益桃,张志,熊辉.金天格胶囊治疗膝骨关节炎的疗效与安全性Meta分析[J].湖南中医药大学学报英文版,2022,42(12):2065-2071.[Click to copy
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| 金天格胶囊治疗膝骨关节炎的疗效与安全性Meta分析 |
| 黄益桃,张志,熊辉 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 系统评价金天格胶囊用于膝骨关节炎治疗的疗效和安全性。方法 计算机检索中国知网(CNKI)、万方数据(WanFang Data)、维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed和Cochrane Library,收集金天格胶囊治疗膝骨关节炎的随机对照试验;检索年限为建库至2022年1月1日;采用RevMan 5.3软件进行数据分析。结果 最终纳入22项研究,共计2174名膝骨关节炎患者。Meta分析结果显示,实验组治疗膝骨关节炎的总体有效率[OR=5.34,95%CI(4.00,7.12),Z=11.37,P<0.01]、视觉模拟评分[OR=-0.79,95%CI(-1.26,-0.32),Z=3.32,P<0.01]、奎森功能演算指数评分[MD=-1.33,95%CI(-2.55,-0.10),Z=2.13,P<0.05]均优于对照组;西安大略麦克马斯特大学骨关节炎指数评分改善情况与对照组比较,差异无统计学意义[MD=-7.85,95%CI(-16.77,1.08),Z=1.72,P>0.05];亚组分析结果显示,金天格胶囊单独使用时,不良反应发生率较对照组低[MD=0.23,95%CI(0.08,0.61),Z=2.95,P<0.01]。结论 金天格胶囊治疗膝骨关节炎具有一定的临床有效性和安全性。 |
| 关键词: 骨关节炎 金天格胶囊 膝 Meta分析 随机对照试验 |
| DOI：10.3969/j.issn.1674-070X.2022.12.017 |
| Received:October 12, 2022 |
| 基金项目:湖南省残疾人康复科研项目(2020XK038); 全国中医全科重点专业基地建设专项资助项目(医协函[2021]666号) |
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| Meta-analysis of the efficacy and safety of Jintiange Capsules in the treatment of knee osteoarthritis |
| HUANG Yitao,ZHANG Zhi,XIONG Hui |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To systematically evaluate the efficacy and safety of Jintiange Capsules for the treatment of knee osteoarthritis(KOA).Methods Randomized controlled trials(RCTs) of Jintiange Capsules for KOA treatment were collected using computerized searches of CNKI, WanFang Data, VIP, CBM, PubMed, and Cochrane Library; the serching period is from the time of establishing database to January 1, 2022. The data analysis was done using RevMan 5.3 software.Results A total of 22 RCTs were included, with a total of 2174 patients with KOA. Meta-analysis results showed that the experimental group had a higher overall efficiency [OR=5.34, 95% CI(4.00, 7.12), Z=11.37, P<0.01], visual analogue score [OR=-0.79, 95% CI(-1.26,-0.32), Z=3.32, P<0.01],and Quessen functional performance index score [MD=-1.33, 95% CI(-2.55,-0.10), Z=2.13, P<0.05] were better than those of the control group; the improvement in the Western Ontario McMaster University osteoarthritis index score was not statistically significant compared with the control group [MD=-7.85,. 95% CI(-16.77, 1.08), Z=1.72, P>0.05]; the results of subgroup analysis showed that the incidence of adverse reactions was lower when Jintiange Capsules were used alone than that in the control group [MD=0.23, 95% CI(0.08, 0.61), Z=2.95, P<0.01].Conclusion Jintiange Capsules have certain clinical efficacy and safety in the treatment of KOA. |
| Key words: osteoarthritis Jintiange Capsules knee meta-analysis randomized controlled trials |
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