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张思淼,彭清华,赵晓威,谢梦州,郭朋,刘婷婷,徐菲.三棱莪术颗粒联合西药治疗肝硬化腹水血瘀水停证的疗效观察[J].湖南中医药大学学报英文版,2022,42(11):1932-1937.[Click to copy
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| 三棱莪术颗粒联合西药治疗肝硬化腹水血瘀水停证的疗效观察 |
| 张思淼,彭清华,赵晓威,谢梦州,郭朋,刘婷婷,徐菲 |
| (湖南中医药大学, 湖南 长沙 410208;中国中医科学院西苑医院肝病科, 北京 100091) |
| 摘要: |
| 目的 探讨三棱莪术颗粒联合西药治疗肝硬化腹水血瘀水停证患者疗效。方法 将肝硬化腹水血瘀水停证患者61例，采用随机数字表法分为观察组和对照组，观察组30例，对照组31例。对照组采用常规西药利尿、护肝、抗病毒等治疗，观察组在对照组的基础上加用三棱莪术颗粒治疗，两组疗程3个月。比较两组患者治疗前后临床症状、腹水消退、肝功能、门静脉内径、脾脏厚度、胆囊壁厚度及有效率。结果 观察组总有效率为90.00%，对照组为58.06%，观察组总有效率高于对照组，差异有统计学意义(P＜0.05)。治疗后，观察组腹膨隆、腹胀、口干、面暗、舌瘀斑、脉涩等血瘀症状改善程度均优于对照组(P＜0.05)；观察组降低肝功能（谷丙转氨酶、谷草转氨酶、γ-谷氨酰转肽酶、总胆红素）、升高血清白蛋白作用优于对照组(P＜0.01)；观察组的腹水消退情况明显优于对照组(P＜0.05)；观察组降低胆囊壁厚度优于对照组(P＜0.05)。结论 三棱莪术颗粒联合西药治疗肝硬化腹水血瘀水停证患者，能有效改善临床症状，促进腹水消退，减轻肝损伤，减轻胆囊炎症，疗效良好，值得临床推广应用。 |
| 关键词: 肝硬化 腹水 血瘀水停证 益气 活血 利水 三棱莪术颗粒 临床观察 |
| DOI：10.3969/j.issn.1674-070X.2022.11.026 |
| Received:March 16, 2022 |
| 基金项目:中国民族医药学会科研项目（2020ZY082-100101）。 |
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| Efficacy observation of Sanleng Ezhu Granules combined with western medicine in the treatment of blood stasis induced water retention pattern of liver cirrhosis with ascites |
| ZHANG Simiao,PENG Qinghua,ZHAO Xiaowei,XIE Mengzhou,GUO Peng,LIU Tinging,XU Fei |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Department of Hepatology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China) |
| Abstract: |
| Objective To explore the efficacy of Sanleng Ezhu Granules combined with western medicine in the treatment of patients suffering from blood stasis induced water retention pattern of liver cirrhosis with ascites. Methods A total of 61 patients suffering from blood stasis induced water retention pattern of liver cirrhosis with ascites were divided into observation group with 30 cases and control group with 31 cases by random number table method. The control group was treated with conventional western drugs of diuresis, liver protection, antiviral and other treatments, and the observation group was treated with Sanleng Ezhu Granules on the basis of the control group. Both groups were treated for 3 months. We compared two groups from clinical symptoms, ascites disappearance, liver function, internal diameter of portal vein, spleen thickness, gallbladder wall thickness and efficacy both before and after treatment. Results The total effective rate of the observation group (90.00%) was higher than that of the control group (58.06%), with a statistically significant difference (P＜0.05). After treatment, the observation group showed improvement in blood stasis symptoms such as abdominal bulge, abdominal bloating, dry mouth, dark facial complexion, ecchymosis on tongue and hesitant pulse than those in the control group (P＜0.05); the effects of observation group on reducing glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase, γ-glutamyl transpeptidase and total bilirubin, and increasing serum albumin were better than those in the control group (P＜0.01); ascites disappearance in the observation group was significantly better than that in the control group (P＜0.05); the reduction of gallbladder wall thickness in the observation group was better than that in the control group (P＜0.05). Conclusion The combination of Sanleng Ezhu Granules and western medicine in the treatment of patients with blood stasis induced water retention pattern of liver cirrhosis with ascites can effectively improve clinical symptoms, promote the ascites disappearance, reduce liver damage, and relieve cholecystitis. It suggests good efficacy and is worthy of clinical promotion and application. |
| Key words: liver cirrhosis ascites blood stasis induced water retention pattern supplementing qi circulating blood promoting urination Sanleng Ezhu Granules clinical observation |
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