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蒋屏,李玉丽,欧正武,袁振仪.基于中医传承辅助平台挖掘欧正武教授治疗儿童肾病综合征的方药规律[J].湖南中医药大学学报英文版,2022,42(11):1910-1915.[Click to copy
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| 基于中医传承辅助平台挖掘欧正武教授治疗儿童肾病综合征的方药规律 |
| 蒋屏,李玉丽,欧正武,袁振仪 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学中医学院, 湖南 长沙 410208) |
| 摘要: |
| 目的 运用中医传承辅助平台，对欧正武教授治疗肾病综合征常用方剂进行数据挖掘并对其治疗肾病综合征用药规律进行探讨，为中医治疗肾病综合征提供新思路。方法 回顾性收集欧教授治疗肾病综合征的方剂，筛选并建立肾病综合征方剂数据库，运用中医传承辅助平台软件挖掘其中的用药规律。结果 筛选欧教授治疗肾病综合征方剂550首，涉及中药86味，炙甘草、黄芪、陈皮、茯苓、白术、荷叶蒂等使用频率最高，用药以甘温性味药物居多，多归脾、肾、肺三脏；出现频率较高的药物组合为炙甘草-黄芪、炙甘草-陈皮、陈皮-黄芪等，演化得到核心组合10条，新处方5首。结论 欧教授治疗肾病综合征强调肺脾肾同调，阴中求阳；补肺阴滋肾水，擅用黄芪固本；平和温补肾阳，降低复发风险；注重微观辨证，活血化瘀。新处方符合欧教授用药规律，可为此后肾病综合征的临床治疗或科研提供思路。 |
| 关键词: 肾病综合征 中医传承辅助平台 儿童 炙甘草 欧正武 配伍规律 |
| DOI：10.3969/j.issn.1674-070X.2022.11.022 |
| Received:April 13, 2022 |
| 基金项目:湖南省重点研发计划项目（2018SK2111）；湖南省教育厅重点项目（18A217）；全国名老中医药专家传承工作室建设项目（国中医药人教函〔2014〕149号）。 |
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| Analyzing medication rules of prescriptions by Professor OU Zhengwu in treating pediatric nephrotic syndrome based on the Chinese Medicine Inheritance Support Platform |
| JIANG Ping,LI Yuli,OU Zhengwu,YUAN Zhenyi |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To employ the Chinese Medicine Inheritance Support Platform to mine the data of Professor OU Zhengwu's common prescriptions for treating nephrotic syndrome, to explore the medication rules for treating nephrotic syndrome, and to provide new ideas for treating nephrotic syndrome with Chinese medicine. Methods Professor OU's prescriptions for treating nephrotic syndrome were collected retrospectively and the database of nephrotic syndrome prescriptions was screened and established. The medication rules were finally mined using the Chinese Medicine Inheritance Support Platform. Results Professor OU's 550 prescriptions for nephrotic syndrome were selected, involving 86 material medicas. The most frequently used drugs were Zhigancao (Radix Glycyrrhizae), Huangqi (Radix Scutellariae), Chenpi (Pericarpium Citri Reticulatae), Fuling (Poria), Baizhu (Rhizoma Atractylodis Macrocephalae) and Heyedi (Folium Nelumbinis Calyx). Most of them were sweet and warm drugs, which mostly accessed to spleen, kidney and lung meridians. The drug combinations with high frequency are Zhigancao (Radix Glycyrrhizae) +Huangqi (Radix Scutellariae), Zhigancao (Radix Glycyrrhizae)+Chenpi (Pericarpium Citri Reticulatae), Chenpi (Pericarpium Citri Reticulatae)+Huangqi (Radix Scutellariae), etc. These have contributed to 10 core combinations and 5 new prescriptions. Conclusion For nephrotic syndrome, Professor OU emphasizes the treatment of lung, spleen and kidney, and seeks yang in yin; he is good at using Huangqi (Radix Scutellariae) to strengthen the body when nourishing lung yin and nourishing kidney water; he mildly warms and tonifies kidney yang to reduce the risk of recurrence; paying attention to syndrome differentiation from the microscopic perspective, he promotes blood circulation and removes blood stasis. The new prescriptions follow Professor OU's medication rules, which can provide new reference for the clinical treatment or scientific research of nephrotic syndrome. |
| Key words: nephrotic syndrome Chinese Medicine Inheritance Support Platform children Zhigancao (Radix Glycyrrhizae) OU Zhengwu combination rules |
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