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宁港,吴悔,李波男,石若冰,周兴.肝细胞生长因子是“乙癸同源”可能的物质基础探讨[J].湖南中医药大学学报英文版,2022,42(10):1720-1724.[Click to copy
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| 肝细胞生长因子是“乙癸同源”可能的物质基础探讨 |
| 宁港,吴悔,李波男,石若冰,周兴 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院男科, 湖南 长沙 410007) |
| 摘要: |
| “乙癸同源”理论由来已久，通过历代医家的发扬与创新，补益肝肾、肝肾互治的理论对于临床疾病特别是男科疾病的治疗具有指导意义；肝细胞生长因子（hepatocyte growth factor, HGF）在促进肝脏细胞再生及损伤修复、关节软骨及韧带肌腱损伤修复方面与中医学“肝主升发”“肝主筋”存在一致性；在促进生殖功能方面与中医学“肾藏精，主生殖”存在一致性；此外，通过中医补益肝肾可以促进体内HGF的产生。由此，提出HGF是“乙癸同源”的可能物质基础，以期进一步丰富“乙癸同源”理论，为其在临床的应用提供科学的依据，提供临床疾病治疗的新思路。 |
| 关键词: 肝细胞生长因子 乙癸同源 肝肾同源 物质基础 补益补肾 肝主筋 |
| DOI：10.3969/j.issn.1674-070X.2022.10.021 |
| Received:March 28, 2022 |
| 基金项目:国家自然科学基金项目（82074444，81673984）；湖南省教育厅重点项目（20A368）；中华中医药学会“青年人才托举工程”项目（2019-QNRC2-C07）；湖南创新型省份建设专项经费资助“湖湘青年英才”支持计划项目（2019RS2041）；湖南省高层次卫生人才225工程医学学科骨干人才培养对象项目（湘卫函〔2019〕196号）；长沙市科技计划项目经费资助长沙市杰出创新青年培养计划项目（kq1802015）；湖南中医药大学中西医结合一流学科开放基金（2020ZXYJH64）；湖南中医药大学研究生创新课题（2021CX69）。 |
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| Hepatocyte growth factor being the possible material basis for “homogeny of Yi and Gui” |
| NING Gang,WU Hui,LI Bonan,SHI Ruobing,ZHOU Xing |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Department of Andrology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| With a long history of "homogeny of Yi and Gui", the theories of "tonifying and replenishing liver and kidney" and "mutual treatment of liver and kidney" have undergone development and innovation by generations of physicians and played a guiding role in treating clinical diseases, especially andrological diseases. In promoting regeneration and damage restoration of liver cells, damage restoration of articular cartilage and ligament tendon, hepatocyte growth factor (HGF) shows consistency with "liver governs ascending and dispersing" and "liver governs sinews" in TCM; in promoting reproductive function, HGF is in accordance with "the kidney stores essence and governs reproduction" in TCM; in addition, tonifying and replenishing liver and kidney in TCM may promote the production of HGF in vivo. Therefore, this paper proposes that HGF is the possible material basis for "homogeny of Yi and Gui", hoping to further enrich the theory and to provide scientific basis for its clinical application and offer new ideas in treating clinical diseases. |
| Key words: hepatocyte growth factor homogeny of Yi and Gui homogeny of liver and kidney material basis tonifying and replenishing liver and kidney liver governs sinews |
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