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张倩,乔赟,时宜蓉.TGF-β1/Smads信号通路与气道重塑的相关性和针刺干预研究进展[J].湖南中医药大学学报英文版,2022,42(9):1570-1573.[Click to copy
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| TGF-β1/Smads信号通路与气道重塑的相关性和针刺干预研究进展 |
| 张倩,乔赟,时宜蓉 |
| (广西中医药大学针灸推拿学院, 广西 南宁 530200) |
| 摘要: |
| 气道重塑是哮喘致死的关键因素，一旦形成，难以逆转。基于转化生长因子-β1（transforming growth factor-β1,TGF-β1）/Smads信号通路与哮喘气道重塑的密切关系，既往研究已初步表明针刺通过调控TGF-β1/Smads信号通路实现抑制气道重塑的发展进程。本文从指标检测、研究方案、取穴标准、针刺时机4个方面对针刺调控TGF-β1/Smads信号通路干预气道重塑的实验研究进行分析并得出解决方案，为今后研究工作提供参考。 |
| 关键词: 气道重塑 哮喘 TGF-β1/Smads信号通路 针刺 进展研究 |
| DOI：10.3969/j.issn.1674-070X.2022.09.026 |
| Received:May 17, 2022 |
| 基金项目:广西自然科学基金面上项目(2017GXNSFAA198201,2020GXNSFAA297021)。 |
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| Research progress in the correlation of TGF-β1/Smads signaling pathway with airway remodeling by acupuncture intervention |
| ZHANG Qian,QIAO Yun,SHI Yirong |
| (College of Acupuncture-Moxibustion and Tuina, Guangxi University of Chinese Medicine, Nanning, Guangxi 530200, China) |
| Abstract: |
| Airway remodeling is a key factor in death from asthma, and once formed, it is difficult to reverse. Based on the close relationship between the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway and airway remodeling in asthma, the previous studies have preliminarily shown that acupuncture suppresses the developmental progression of airway remodeling by regulating the TGF-β1/Smads signaling pathway. In this paper, the experimental research on the intervention of acupuncture on TGF-β1/Smads signaling pathway in airway remodeling was analyzed and solutions were produced from four aspects: indicator detection, research scheme, acupoint selection standard and acupuncture timing, aiming to provide reference for the future research. |
| Key words: airway remodeling asthma TGF-β1/Smads signaling pathway acupuncture research progress |
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