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刘学武,张乐佳,宋军,吴颖,邹振兴,徐康平,陈静,张宗利.蓝金口服液治疗上呼吸道感染（风热表证）的作用研究[J].湖南中医药大学学报英文版,2022,42(9):1457-1464.[Click to copy
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| 蓝金口服液治疗上呼吸道感染（风热表证）的作用研究 |
| 刘学武,张乐佳,宋军,吴颖,邹振兴,徐康平,陈静,张宗利 |
| (新药药效与安全性评价湖南省重点实验室, 湖南 长沙 410331;湖南普瑞玛药物研究中心有限公司, 湖南 长沙 410331;湖南中嘉生物医药有限公司, 湖南 长沙 410336;中南大学湘雅药学院, 湖南 长沙 410013) |
| 摘要: |
| 目的 探讨蓝金口服液治疗上呼吸道感染（风热表证）的药效学作用。方法 分别采用体内、体外实验考察蓝金口服液的抗菌和抗病毒药效作用。采用小鼠乙酸扭体实验、小鼠热板法镇痛实验、酵母致大鼠发热实验、大鼠足趾汗液分泌实验分别考察蓝金口服液的镇痛、解热和发汗作用。结果 蓝金口服液对多种临床分离菌均有体外抑制作用。乙型溶血性链球菌、大肠埃希菌、肺炎克雷伯菌和白假丝酵母菌的MIC为25～200 mg/mL；蓝金口服液体外抑制呼吸道合胞病毒和甲型流感病毒感染细胞的IC50分别为3.50、6.58 mg/mL，安全指数SI分别为194和147。体内研究显示，蓝金口服液能显著降低小鼠感染细菌（金黄色葡萄球菌、肺炎链球菌、乙型溶血性链球菌）或甲型流感病毒后的死亡率，显著延长生存天数，并显著减小感染甲型流感病毒后的肺指数。蓝金口服液具有显著的镇痛、解热和发汗作用。结论 蓝金口服液对上呼吸道感染（风热表证）具有显著治疗效果。 |
| 关键词: 上呼吸道感染 风热表证 蓝金口服液 抗菌 抗病毒 镇痛 解热 发汗 |
| DOI：10.3969/j.issn.1674-070X.2022.09.007 |
| Received:November 19, 2021 |
| 基金项目:湖南省高新技术产业科技创新引领计划项目(2020GK4083)。 |
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| Effects of Lanjin Oral Liquid on upper respiratory tract infection (wind-heat exterior syndrome) |
| LIU Xuewu,ZHANG Lejia,SONG Jun,WU Ying,ZOU Zhenxing,XU Kangping,CHEN Jing,ZHANG Zongli |
| (Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Changsha, Hunan 410331, China;Hunan Prima Pharmaceutical Research Center Co. Ltd, Changsha, Hunan 410331, China;Hunan Zhongjia Bio-pharmaceutical Co., Ltd., Changsha, Hunan 410336, China;Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China) |
| Abstract: |
| Objective To explore the pharmacodynamic effects of Lanjin Oral Liquid in the treatment of upper respiratory tract infection (wind-heat exterior syndrome). Methods In vivo and in vitro experiments were conducted to investigate the antibacterial and antiviral effects of Lanjin Oral Liquid. The analgesic, antipyretic and sweating effects of Lanjin Oral Liquid were investigated through acetic acid writhing experiment in mice, hot plate analgesic experiment in mice, yeast-induced febrile experiment in rats and sweat secretion experiment in rats. Results Lanjin Oral Liquid had in vitro inhibitory effect on various clinical isolated bacterium. The MIC of Strptococous hemolyticus, Escherichiacoli, Klebsiella pneumoniae and Monilia albicans were all in the range of 25~200 mg/mL; the IC50 of Lanjin Oral Liquid against respiratory syncytial virus and influenza virus A infected cells in vitro were 3.50 mg/mL and 6.58 mg/mL respectively, and the saftey index SI were 194 and 147 respectively. In vivo studies showed that Lanjin Oral Liquid can significantly reduce the mortality of mice infected with bacteria (Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus b hemolytic) or influenza virus A, can significantly prolong the survival days, and significantly reduce the lung index after infection with influenza A virus. Lanjin Oral Liquid has significant analgesic, antipyretic and sweating effects. Conclusion Lanjin Oral Liquid has significant therapeutic effects on upper respiratory tract infection (windheat surface syndrome). |
| Key words: upper respiratory tract infection wind-heat exterior syndrome Lanjin Oral Liquid antibacterial antiviral analgesic antipyresis sweating |
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