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贺佐梅,徐云,邓天好,郜文辉,李丽,刘双浩,周婉双,曾普华.7435份非小细胞肺癌病案中医用药规律分析[J].湖南中医药大学学报英文版,2022,42(7):1157-1163.[Click to copy
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| 7435份非小细胞肺癌病案中医用药规律分析 |
| 贺佐梅,徐云,邓天好,郜文辉,李丽,刘双浩,周婉双,曾普华 |
| (湖南省中医药研究院附属医院, 湖南 长沙 410007;湘潭市第一人民医院, 湖南 湘潭 411101;湖南中医药大学, 湖南 长沙 410208;湖南省中医药研究院附属医院, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 运用数据挖掘技术与方法分析湖南省中医药研究院附属医院非小细胞肺癌（non small-cell lung carcinoma,NSCLC）住院病案，探讨NSCLC的中医处方用药分布规律，为NSCLC临床的辨证、治疗及用药提供参考。方法 通过对7435份NSCLC病案进行回顾性调查分析，筛选出与NSCLC有关的医案，提取其中的中药处方，并应用频次统计分析、复杂网络分析、关联规则分析及因子分析对处方进行数据挖掘，分析NSCLC的中医处方用药分布规律。结果 通过对7435份NSCLC病案进行数据挖掘分析，NSCLC的中医处方用药分布规律为：NSCLC临床用药以甘草、黄芪、白术、白花蛇舌草、茯苓、半夏、半枝莲、人参、枸杞子、女贞子等药物用药频次最高；药物功效类总频次分析发现治疗NSCLC以清热解毒药、补气药、补阴药、化痰止咳平喘药、化瘀通络药等为主；因子分析结果亦表明，NSCLC中医临床主要以益气、补阴、化痰、化瘀、解毒等治法为主，辅以健脾、理气、利水等治法；复杂网络分析和关联规则分析得出肺癌常用药对分别为：黄芪-女贞子；白术-茯苓、白花蛇舌草；白术-枸杞子、黄芪；白术-枸杞子；黄芪-枸杞子；黄芪-人参、白术等。结论 7435份NSCLC临床用药数据揭示了治疗NSCLC以益气、补阴、化痰、化瘀、解毒等为主，辅以健脾、理气、利水等治法，为临床治疗NSCLC用药提供了参考。 |
| 关键词: 非小细胞肺癌 益气 补阴 化瘀 化痰 解毒 |
| DOI：10.3969/j.issn.1674-070X.2022.07.015 |
| Received:January 19, 2022 |
| 基金项目:抗肿瘤中药创制技术湖南省工程研究中心项目（湘发改高技〔2015〕1085号）；湖南创新型省份建设专项经费资助项目（2019SK4013）；湖南省自然科学基金青年基金项目（2021JJ40310）；湖南省中医药管理局资助项目（2021176）；湖南省中医药研究院科研课题（201901）。 |
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| Analysis of the medication rules of traditional Chinese medicine in 7435 cases of non-small cell lung cancer |
| HE Zuomei,XU Yun,DENG Tianhao,GAO Wenhui,LI Li,LIU Shuanghao,ZHOU Wanshuang,ZENG Puhua |
| (Hunan Academy of Traditional Chinese Medicine Affiliated Hospital, Changsha, Hunan 410007, China;The First Hospital of Xiangtan, Xiangtan, Hunan 411101, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Academy of Traditional Chinese Medicine Affiliated Hospital, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To analyze the inpatient medical records of non-small cell lung carcinoma (NSCLC) by using data mining techniques and methods, and to explore the distribution of traditional Chinese medicine (TCM) prescriptions for NSCLC, and to provide reference for the differentiation, treatment and medication of NSCLC in clinic. Methods Through the retrospective investigation and analysis of 7435 cases of NSCLC, NSCLC-related medical cases were screened out, TCM prescriptions were extracted, and frequency statistics, complex network analysis, association rule analysis and factor analysis were used to analyze the prescriptions, so as to analyze the distribution rules of TCM prescriptions in NSCLC. Results Through data mining research on 7435 NSCLC cases, it was found that the distribution rules of NSCLC prescription drugs were as follows:Gancao (Glycyrrhizae Radix Et Rhizoma), Huangqi (Astragali Radix), Baizhu (Atractylodis Macrocephalae Rhizoma), Baihuasheshecao (Hedyotis Diffusa), Fuling (Poria), Banxia (Pinelliae Rhizoma), Banzhilian (Scutellariae Barbatae Herba), Renshen (Ginseng Radix Et Rhizoma), Gouqizi (Lycii Fructus), Nvzhenzi (Ligustri Lucidi Fructus) and other drugs were the most frequently used in NSCLC. Total frequency analysis of drug efficacy showed that the treatment of NSCLC was mainly heat clearing and detoxifying drugs, Qi tonifying drugs, Yin tonifying drugs, phlegm resolving, cough relieving and asthma relieving drugs, blood stasis removing and collateral dredging drugs, etc. Factor analysis results also showed that the clinical treatment methods of NSCLC in TCM were mainly based on invigorating Qi, nourishing Yin, dissipating phlegm, removing blood stasis and detoxifying, supplemented by invigorating spleen, regulating Qi and benefiting water. The analysis of complex network and association rules of the prescription revealed that the commonly used pairs of drugs for NSCLC were:Huangqi (Astragali Radix)-Nvzhenzi (Ligustri Lucidi Fructus); Baizhu (Atractylodis Macrocephalae Rhizoma)-Fuling (Poria), Baihuasheshecao (Hedyotis Diffusa); Baizhu (Atractylodis Macrocephalae Rhizoma)-Gouqizi (Lycii Fructus), Huangqi (Astragali Radix); Baizhu (Atractylodis Macrocephalae Rhizoma)-Gouqizi (Lycii Fructus); Huangqi (Astragali Radix)-Gouqizi (Lycii Fructus); Huangqi (Astragali Radix)-Renshen (Ginseng Radix Et Rhizoma), Baizhu (Atractylodis Macrocephalae Rhizoma) etc. Conclusions According to 7435 NSCLC clinical medication data, the treatment of NSCLC mainly involves supplementing Qi, nourishing Yin, resolving phlegm, removing blood stasis and detoxifying, supplemented by invigorating spleen, regulating Qi and benefiting water, which provides reference for clinical treatment of NSCLC. |
| Key words: non-small cell lung cancer invigorating Qi nourishing Yin removing blood stasis dissipating phlegm detoxifying |
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