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卢英琦,孙忠人,胡其回,王瑞琪,尹洪娜.NLRP3炎症小体与中药提取物调节脑脊髓疾病机制[J].湖南中医药大学学报英文版,2022,42(6):1051-1056.[Click to copy
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| NLRP3炎症小体与中药提取物调节脑脊髓疾病机制 |
| 卢英琦,孙忠人,胡其回,王瑞琪,尹洪娜 |
| (黑龙江中医药大学, 黑龙江 哈尔滨 150040;黑龙江中医药大学附属第二医院, 黑龙江 哈尔滨 150001) |
| 摘要: |
| NLRP3炎症小体是炎症反应过程中极为重要的因子，能参与多种疾病尤其是脑脊髓疾病的发生发展过程，可干预中枢神经系统的调节与恢复。大量研究表明，中药相应提取物对NLRP3具有良好调节作用。本文就NLRP3炎症小体启动与激活过程，在脊髓损伤、动脉粥样硬化、抑郁症、缺血性脑卒中等脑脊髓疾病中的机制效应，以及中药提取物治疗相应疾病的动物实验研究进行综述，为临床调节NLRP3炎症小体提供有效依据。 |
| 关键词: NLRP3炎症小体 炎症 脑脊髓疾病 中药提取物 脊髓损伤 动脉粥样硬化 抑郁症 缺血性脑卒中 |
| DOI：10.3969/j.issn.1674－070X.２０22.06.030 |
| Received:September 11, 2021 |
| 基金项目:国家自然科学基金面上项目(81873378)。 |
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| Mechanism of NLRP3 inflammasome and traditional Chinese medicine extract on regulation of cerebrospinal diseases |
| LU Yingqi,SUN Zhongren,HU Qihui,WANG Ruiqi,YIN Hongna |
| (Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China) |
| Abstract: |
| NLRP3 inflammasome is a very important factor in the process of inflammatory response. It can participate in the occurrence and development of a variety of diseases, especially cerebrospinal diseases, and can intervene in the regulation and recovery of the central nervous system. A large number of studies have shown that traditional Chinese medicine and its corresponding extracts have a good regulatory effect on NLRP3. This article mainly reviews the start-up and activation process of NLRP3 inflammasome, and its mechanism effects of cerebrospinal diseases such as spinal cord injury, atherosclerosis, depression and ischemic stroke, as well as the animal experimental studies of traditional Chinese medicine extracts in the treatment of these diseases, so as to provide effective basis for clinical regulation of NLRP3 inflammasome. |
| Key words: NLRP3 inflammasome inflammation cerebrospinal diseases traditional Chinese medicine extracts spinal cord injury atherosclerosis depression ischemic stroke |
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