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刘慧,李青,魏瑞丰,赵群,刘志豪,李永春.督脉半灸法联合右归丸对青春期功能失调性子宫出血肾阳虚型患者性激素水平的影响[J].湖南中医药大学学报英文版,2022,42(6):994-998.[Click to copy
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| 督脉半灸法联合右归丸对青春期功能失调性子宫出血肾阳虚型患者性激素水平的影响 |
| 刘慧,李青,魏瑞丰,赵群,刘志豪,李永春 |
| (山东中医药大学, 山东 济南 250355;济南市妇幼保健院, 山东 济南 250001) |
| 摘要: |
| 目的 观察督脉半灸法联合右归丸治疗青春期功能失调性子宫出血（juvinile uterine bleeding,JUB）肾阳虚型患者的临床疗效。方法 将68例JUB肾阳虚型患者随机分为对照组与治疗组，各34例。对照组采用口服右归丸治疗，治疗组在对照组的基础上加用督脉半灸法。治疗3个月后，观察两组患者临床总有效率、治疗前后临床症状改善情况、控制出血时间、完全止血时间及血清性激素[雌二醇(estradiol,E2)、孕酮(progesterone,P)、促卵泡激素（follicle stimulating hormone,FSH）、黄体生成素（luteinizing hormone,LH）]水平。结果 治疗后，治疗组总有效率明显优于对照组(P＜0.05）；两组中医症状总积分低于治疗前(P＜0.05），且治疗组低于对照组（P＜0.05）；治疗组在控制出血时间、完全止血时间上均明显短于对照组(P＜0.05）；治疗后两组仅P、FSH水平较治疗前提高（P＜0.05），且治疗组P、FSH水平高于对照组（P＜0.05）。结论 督脉半灸法联合右归丸治疗肾阳虚型JUB具有良好的疗效，可有效改善患者的临床症状、调整性激素水平、改善下丘脑-垂体-卵巢轴激素间的反馈调节机制，值得临床推广应用。 |
| 关键词: 青春期功能失调性子宫出血 督脉半灸法 右归丸 肾阳虚 性激素水平 下丘脑-垂体-卵巢轴 |
| DOI：10.3969/j.issn.1674－070X.２０22.06.019 |
| Received:August 24, 2021 |
| 基金项目:山东省中医药科技发展计划(2019-0060)。 |
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| Effect of Dumai Semi-moxibustion combined with Yougui Pill on sex hormone levels in patients with juvenile uterine bleeding of kidney-Yang deficiency type |
| LIU Hui,LI Qing,WEI Ruifeng,ZHAO Qun,LIU Zhihao,LI Yongchun |
| (Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong 250355, China;Ji'nan Maternity and Child Care Hospital, Ji'nan, Shandong 250001, China)) |
| Abstract: |
| Objective To observe the clinical efficacy of Dumai Semi-moxibustion combined with Yougui Pill in the treatment of juvenile uterine bleeding (JUB) with kidney-Yang deficiency type. Methods A total of 68 patients with kidney-Yang deficiency type of JUB were randomly divided into control group and treatment group, with 34 cases in each group. The control group was treated with oral Yougui Pill, and the treatment group was treated with Dumai Semi-moxibustion on the basis of the control group. After three months of treatment, the total clinical effective rate, the improvement of clinical symptoms before and after treatment, the time of bleeding control, the time of complete hemostasis and the levels of serum sex hormones estradiol (E2), progesterone (P), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were observed. Results After treatment, the total effective rate of the treatment group was significantly better than that of the control group (P<0.05); the total score of TCM symptoms in the two groups was lower than before treatment (P<0.05), and treatment group was lower than that in the control group (P<0.05); the time of bleeding control and the time of complete hemostasis in the treatment group were significantly shorter than control group (P<0.05); after treat-ment, only the levels of P and FSH in the two groups were higher than those before treatment (P<0.05), and the levels of P and FSH in the treatment group were higher than those in the control group (P<0.05). Conclusion Dumai Semi-moxibustion combined with Yougui Pill has good curative effect in the treatment of kidney-Yang deficiency type of JUB. It can effectively improve the clinical symptoms of patients, adjust the level of sex hormones, and improve the feedback regulation mechanism between hormones of hypothalamus-pituitary-ovary axis. It is worthy of clinical application. |
| Key words: juvenile uterine bleeding Dumai Semi-moxibustion Yougui Pill kidney-Yang deficiency sex hormone level hypothalamus-pituitary-ovary axis |
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