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付越,陈成,谢梦洲,雷慧珺,李亮,李丰.中医药调节微小核糖核酸干预胃癌的研究进展[J].湖南中医药大学学报英文版,2022,42(5):862-866.[Click to copy
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| 中医药调节微小核糖核酸干预胃癌的研究进展 |
| 付越,陈成,谢梦洲,雷慧珺,李亮,李丰 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学 中医诊断学湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学 中医心肺病证辨证与药膳食疗重点研究室, 湖南 长沙 410208;长沙医学院, 湖南 长沙 410219) |
| 摘要: |
| 胃癌（gastric cancer, GC）是一种发病率和死亡率都居高不下的恶性肿瘤。微小核糖核酸（microRNA， miRNA）是肿瘤发生和发展过程的重要调控因子，在胃癌等多种肿瘤的致癌机制、肿瘤发生环境和抑癌作用等方面，miRNA通过影响相关细胞信号通路和调控靶向基因的方式发挥了重要的调控作用。中医药通过调节miRNA干预胃癌的作用机制可从以下几个方面进行分析：中医药通过miRNA介导胃癌肿瘤细胞内外环境的变化；中医药可以针对胃癌特异性miRNA进行有效干预；中医药通过miRNA调节机体的免疫功能。通过总结miRNA对胃癌发挥作用的主要途径和分析中医药调节miRNA干预胃癌的机制，明确了miRNA在胃癌诊断、治疗中的重要性，为中医药防治胃癌提供有价值的参考。 |
| 关键词: 胃癌 微小核糖核酸 中医药 细胞信号通路 靶向基因 肿瘤微环境 |
| DOI：10.3969/j.issn.1674-070X.2022.05.029 |
| Received:March 07, 2022 |
| 基金项目:湖南省自然科学基金项目（2019JJ40221）。 |
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| Research progress of traditional Chinese medicine intervention in gastric cancer by regulating MicroRNA |
| FU Yue,CHEN Cheng,XIE Mengzhou,LEI Huijun,LI Liang,LI Feng |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Key Laboratory of TCM Diagnostics of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Key Laboratory of TCM Cardiopulmonary Disease Syndrome Differentiation & Medicine Diet Therapy of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Changsha Medical University, Changsha, Hunan 410219, China) |
| Abstract: |
| gastric cancer (GC) is a malignant tumor with high morbidity and mortality. MicroRNA (miRNA) is an essential regulatory factor in tumor genesis and development. By affecting related cellular signaling pathways and manipulating the expression of target genes, miRNA plays an important regulatory role in the mechanism of carcinogenesis, tumorigenic environment and tumor inhibition of various tumors including GC. The mechanism of traditional Chinese medicine (TCM) intervening in GC through miRNA can be analyzed from the following aspects:TCM mediates the changes in the internal and external environment of GCr cells via miRNA; TCM can effectivelty intervene against specific miRNA of GC; TCM regulates immune function through miRNA. By summarizing the main ways of miRNA playing a role in GC and analyzing the mechanism of TCM regulating miRNA intervening in GC, the importance of miRNA in the diagnosis and treatment of GC is clarified, which provides a valuable reference for the prevention and treatment of GC by TCM. |
| Key words: gastric cancer microRNA traditional Chinese medicine cellular signaling pathway targeted gene tumor microenvironment |
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