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刘涛,欧阳林旗,陈镇,徐寅,吴金鸿,邓桂明.中药调控色氨酸-肠道菌群代谢治疗溃疡性结肠炎的研究进展[J].湖南中医药大学学报英文版,2022,42(2):324-331.[Click to copy
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| 中药调控色氨酸-肠道菌群代谢治疗溃疡性结肠炎的研究进展 |
| 刘涛,欧阳林旗,陈镇,徐寅,吴金鸿,邓桂明 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学药学院, 湖南 长沙 410208) |
| 摘要: |
| 溃疡性结肠炎（ulcerative colitis，UC）是一种慢性、易复发的炎症性肠病，临床上以血性腹泻、腹痛等为特征症状。UC的发病机制与肠黏膜免疫异常、肠道菌群失调、色氨酸代谢紊乱等密切相关。色氨酸-肠道菌群代谢能促进机体肠道免疫功能的发育和完善，因而对缓解肠道炎症具有重要意义。中医药在治疗UC方面具有一定的特色和优势，许多中药及中药复方被证实有明显的免疫调节作用。本文就UC中色氨酸-肠道菌群代谢对肠黏膜屏障功能和免疫功能的影响，以及中药调控色氨酸-肠道菌群代谢治疗UC的研究进展进行综述，以期为中药治疗UC的机制研究与新药研发提供参考。 |
| 关键词: 溃疡性结肠炎 色氨酸-肠道菌群代谢 免疫功能 肠道炎症 中药 |
| DOI：10.3969/j.issn.1674-070X.2022.02.027 |
| Received:December 16, 2021 |
| 基金项目:国家自然科学基金项目（81904176）；湖南省自然科学基金项目（2020JJ5435，2018JJ6040）；湖南省教育厅重点项目（19A372）；湖南省中医药科研计划重点项目（2021016，201986）；湖南中医药大学科研基金项目（2019XJJJ025）。 |
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| Research progress on traditional Chinese medicine regulating tryptophan-gut microbiota metabolism in the treatment of ulcerative colitis |
| LIU Tao,OUYANG Linqi,CHEN Zhen,XU Yin,WU Jinhong,DENG Guiming |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Ulcerative colitis (UC) is a chronic, recurring inflammatory bowel disease, clinically characterized by bloody diarrhea and abdominal pain. The pathogenesis of UC is closely related to abnormal intestinal mucosal immunity, imbalance of gut microbiota, and tryptophan metabolism disorder. The tryptophan-gut microbiota metabolism can promote the development and perfection of the body's intestinal immune function, so it is of great significance to alleviate intestinal inflammation. Traditional Chinese medicine has characteristics advantages in UC treatment. Many single herb and traditional Chinese medicine compound were proved having obvious effect of immunological regulation. In this review, we focused on the effects of tryptophan-gut microbiota metabolism on intestinal mucosal barrier function and immune function in UC, and the research progress of traditional Chinese medicine on regulating tryptophan-gut microbiota metabolism for the treatment of UC, with a view to providing references for mechanistic studies of traditional Chinese medicine for the treatment of UC and the development of new drugs. |
| Key words: ulcerative colitis tryptophan-gut microbiota metabolism immune function intestinal inflammation traditional Chinese medicine |
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