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张思,范菲,韩斐.基于数据挖掘及网络药理学探讨韩斐教授治疗小儿过敏性鼻炎经验[J].湖南中医药大学学报英文版,2022,42(1):165-172.[Click to copy
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| 基于数据挖掘及网络药理学探讨韩斐教授治疗小儿过敏性鼻炎经验 |
| 张思,范菲,韩斐 |
| (中国中医科学院广安门医院儿科, 北京 100053) |
| 摘要: |
| 目的 探讨韩斐教授治疗小儿过敏性鼻炎的临床用药规律以及核心药对的潜在作用机制。方法 收集2019年4月至2021年4月于中国中医科学院广安门医院韩斐教授门诊就诊的过敏性鼻炎患儿的初诊处方，建立处方数据库。采用用药频数统计及关联规则算法挖掘韩斐教授治疗小儿过敏性鼻炎的核心药对，并利用网络药理学方法对核心药对的作用机制进行分析。结果 共有178首处方纳入研究，白芷-辛夷药对为韩斐教授治疗本病的核心药对；白芷-辛夷药对的重要活性成分有β-谷甾醇、豆甾醇等；活性成分与疾病交集22个靶点；药对活性成分抗调控的主要信号通路有钙离子信号通路、IL-17信号通路、TNF信号通路等。结论 韩斐教授脏腑辨证从肺、心、肝、脾论治小儿过敏性鼻炎，以疏散风邪、疏肝健脾养心为法，核心药对是白芷-辛夷；白芷-辛夷药对可能通过钙离子信号通路、IL-17信号通路、TNF信号通路起到改善过敏性鼻炎的作用。 |
| 关键词: 过敏性鼻炎 数据挖掘 网络药理 药对 白芷 辛夷 儿童 |
| DOI：10.3969/j.issn.1674-070X.2022.01.030 |
| Received:September 21, 2021 |
| 基金项目:中央级公益性科研院所基本科研业务费专项资金资助项目（ZZ13-024-05，ZZ15-XY-PT-03）。 |
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| Explore professor Han Fei's experience in treating allergic rhinitis on children based on data mining and network pharmacology |
| ZHANG Si,FAN Fei,HAN Fei |
| (Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China) |
| Abstract: |
| Objective To explore the clinical medication rule of professor Han Fei in the treatment of children with allergic rhinitis and the potential mechanism of the core drug pair. Methods The first-diagnosed prescriptions of children with allergic rhinitis who visited professor Han Fei's outpatient clinic of Guang'anmen Hospital of China Academy of Chinese Medical Sciences from April 2019 to April 2021 were collected, and a prescription database was established. Drug frequency statistics and association rule algorithms were used to excavate professor Han Fei's core drug pairs for the treatment of children with allergic rhinitis, and network pharmacology method was used to analyze the mechanism of action of the core drug pairs. Results A total of 178 prescriptions were included in the study. The Baizhi (Angelicae Dahuricae Radix)-Xinyi (Magnoliae Flos) drug pair was the core drug pair for professor Han Fei to treat this disease; the important active ingredients of the Baizhi (Angelicae Dahuricae Radix)-Xinyi (Magnoliae Flos) were β-sitosterol, stigmasterol; active ingredients and disease intersected 22 targets; the main signal pathways that drugs resist regulation of active ingredients included calcium signaling pathway, IL-17 signaling pathway, TNF signaling pathway, etc. Conclusion Professor Han Fei treats children with allergic rhinitis through visceral theory which coordinating the lung, heart, liver, and spleen, to dispel wind pathogens, and to soothe the liver and invigorate the spleen and nourish the heart. The core drug pair is Baizhi (Angelicae Dahuricae Radix)-Xinyi (Magnoliae Flos); the drug pair Baizhi (Angelicae Dahuricae Radix)-Xinyi (Magnoliae Flos) may play a role in improving children with allergic rhinitis through calcium signaling pathway, IL-17 signaling pathway and TNF signaling pathway. |
| Key words: allergic rhinitis data mining network pharmacology drug pair Baizhi (Angelicae Dahuricae Radix) Xinyi (Magnoliae Flos) children |
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